Total synthesis of natural products

Summary

Complex polycyclic natural products are chosen to illustrate the evolution of the state-of-the-art of the field, the interplay between strategy and new reactions as well as the importance of implementing multi-bond forming processes in a synthesis.

Content

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Keywords

Retro-synthetic analysis, Synergism between strategy and new reactions, Domino reactions, multicomponent reactions, Oxidative coupling, Pattern Recognition, Hidden Symmetry, C-H Functionalization, Asymmetric organocatalysis

 

Learning Prerequisites

Recommended courses

General knowledge of organic reactions. Basic knowledge of retro-syntheis. EPFL lectures fonctions et réactions organiques I and II, synthèse asymétrique, target synthesis, structure and reactivity or equivalent courses.

Learning Outcomes

By the end of the course, the student must be able to:

• Draw reaction mechanism
• Analyze synthetic route
• Elaborate synthetic scheme
• Design synthetic strategy

Supervision

Office hours	Yes
Assistants	Yes
Forum	Yes

Resources

Ressources en bibliothèque

• Classics in Total Synthesis II : / Nicolaou
• Workbook for Organic Synthesis / Warren
• Classics in Total Synthesis III : / Nicolaou
• Organic Synthesis : The Disconnection Approach / Wyatt
• Classics in Total Synthesis : Targets, Strategies, Methods / Nicolaou

Websites

• http://scgc.epfl.ch/telechargement_cours_chimie

Moodle Link

• https://go.epfl.ch/CH-438