Fiches de cours

The making of an innovative medicine


Lecturer(s) :

Clerc Roger G.




Every year


Next time Fall 2019


To expose participants to translational research (from bench to bedside and back) and drug discovery


Through a logical series of presentations both from the participants and the lecturer (flipped classroom format, oral presentations, workshops) on the making of an innovative medicine, the entire and complex process starting from the therapeutic target identification up until the clinical development and use in clinical practice of a new molecular entity (NME) will be addressed and discussed.


The course is divided in twelve sections of each 2 periods of 45 minutes :

Section 1          Scope of the course, general organization, case study

Section 2          Historical perspective: the modern pharmacy

Section 3          Introduction to translational research: crossing the bridge

Section 4          Therapeutic target identification I & II

Section 5          Structure based drug design, medicinal chemistry, low/high throughput screening assays, multiple paralell parameters optimization MDO

Section 6          Therapeutic peptides and biologicals: today's - tomorrow's pharmacy

Section 7          Personalized Healthcare (PHC) precision medicine

Section 8          Pharmacogenetic polymorphisms, Pharmacogenomics

Section 9          In vivo pharmacology, investigative toxicology

Section 10         Clinical research, phase 0, phase I, II, III, IV

Section 11         Health Hackathon - Hacking medicine I

Section 12         Health Hackathon - Hacking medicine II


Minimum 4 participants

Maximum 25 participants


This interactive introductory course to drug discovery and translational biomedical research (from the bench to bedside and back) involves an active participation of the attendants in form of in classroom presentations (flipped classroom). A detailed instruction for authors is made available at the beginning of the course. All participants are given the opportunity to practice the concept of an health hackathon focused on innovative therapeutic solutions. The presentations serve as course evaluation.

Learning Outcomes


Translational biomedical research/Drug discovery

Learning Prerequisites

Required courses

Basic Molecular Biology, Cellular Signaling, Pharmacology



'A prescription for change : the looming crisis in drug development' Pr M. Kinch UNC  Press(2017) ISBN 978-1-4696-3062-5

In the programs

Reference week

      Exercise, TP
      Project, other


  • Autumn semester
  • Winter sessions
  • Spring semester
  • Summer sessions
  • Lecture in French
  • Lecture in English
  • Lecture in German