Structure and reactivity
Summary
To develop a detailed knowledge of the key steps of advanced modern organic synthesis going beyond classical chemistry of olefins and carbonyls.
Content
1. Repetition of the chemistry of olefins and carbonyls
- limitations
2. Rearrangements
- Sigmatropic: Claisen, Ireland-Claisen, Johnson-Claisen, Eschenmoser, Wittig, Evans-Mislow
- Reactive intermediates : cations, carbenes, nitrenes
3. Cyclisations and Cycloadditions
- Pericyclic reactions
- Diels-Alder (normal, hetero, inverse electron demand)
- Dipolar cycloadditions
4. Radical- and Photochemistry
5. Strrategy of Umpolung
- Stoichiometric and catalytic
6. Metal-catalysis in Organic Chemistry
- Cross-coupling and metathesis
- Olefins and C-H bonds functionalization
- Synthesis of carbo- and heterocyclic systems
Learning Outcomes
By the end of the course, the student must be able to:
- Develop a detailed knowledge of the key steps of advanced modern organic synthesis going beyond classical chemistry of olefins and carbonyls
Transversal skills
- Assess one's own level of skill acquisition, and plan their on-going learning goals.
- Demonstrate the capacity for critical thinking
Teaching methods
ex cathedra lecture
Assessment methods
final oral exam
Resources
Websites
Moodle Link
Dans les plans d'études
- Semestre: Automne
- Forme de l'examen: Oral (session d'hiver)
- Matière examinée: Structure and reactivity
- Cours: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel
- Semestre: Automne
- Forme de l'examen: Oral (session d'hiver)
- Matière examinée: Structure and reactivity
- Cours: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel
- Forme de l'examen: Oral (session d'hiver)
- Matière examinée: Structure and reactivity
- Cours: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel