Coursebooks

Structure and reactivity

CH-432

Lecturer(s) :

Cramer Nicolai

Language:

English

Summary

To develop a detailed knowledge of the key steps of advanced modern organic synthesis going beyond classical chemistry of olefins and carbonyls.

Content

1. Repetition of the chemistry of olefins and carbonyls
- limitations
2. Rearrangements
- Sigmatropic: Claisen, Ireland-Claisen, Johnson-Claisen, Eschenmoser, Wittig, Evans-Mislow
- Reactive intermediates : cations, carbenes, nitrenes
3. Cyclisations and Cycloadditions
- Pericyclic reactions
- Diels-Alder (normal, hetero, inverse electron demand)
- Dipolar cycloadditions
4. Radical- and Photochemistry
5. Strrategy of Umpolung
- Stoichiometric and catalytic
6. Metal-catalysis in Organic Chemistry
- Cross-coupling and metathesis
- Olefins and C-H bonds functionalization
- Synthesis of carbo- and heterocyclic systems

Learning Outcomes

By the end of the course, the student must be able to:

• Develop a detailed knowledge of the key steps of advanced modern organic synthesis going beyond classical chemistry of olefins and carbonyls

Transversal skills

• Assess one's own level of skill acquisition, and plan their on-going learning goals.
• Demonstrate the capacity for critical thinking

Teaching methods

ex cathedra lecture

Assessment methods

final oral exam

Resources

Websites

• http://scgc.epfl.ch/telechargement_cours_chimie