Structure and reactivity
Summary
To develop a detailed knowledge of the key steps of advanced modern organic synthesis going beyond classical chemistry of olefins and carbonyls.
Content
1. Repetition of the chemistry of olefins and carbonyls
- limitations
2. Rearrangements
- Sigmatropic: Claisen, Ireland-Claisen, Johnson-Claisen, Eschenmoser, Wittig, Evans-Mislow
- Reactive intermediates : cations, carbenes, nitrenes
3. Cyclisations and Cycloadditions
- Pericyclic reactions
- Diels-Alder (normal, hetero, inverse electron demand)
- Dipolar cycloadditions
4. Radical- and Photochemistry
5. Strrategy of Umpolung
- Stoichiometric and catalytic
6. Metal-catalysis in Organic Chemistry
- Cross-coupling and metathesis
- Olefins and C-H bonds functionalization
- Synthesis of carbo- and heterocyclic systems
Learning Outcomes
By the end of the course, the student must be able to:
- Develop a detailed knowledge of the key steps of advanced modern organic synthesis going beyond classical chemistry of olefins and carbonyls
Transversal skills
- Assess one's own level of skill acquisition, and plan their on-going learning goals.
- Demonstrate the capacity for critical thinking
Teaching methods
ex cathedra lecture
Assessment methods
final oral exam
Resources
Websites
Moodle Link
In the programs
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Structure and reactivity
- Lecture: 2 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Structure and reactivity
- Lecture: 2 Hour(s) per week x 14 weeks
- Type: optional
- Exam form: Oral (winter session)
- Subject examined: Structure and reactivity
- Lecture: 2 Hour(s) per week x 14 weeks
- Type: optional
Reference week
| Mo | Tu | We | Th | Fr | |
| 8-9 | |||||
| 9-10 | |||||
| 10-11 | |||||
| 11-12 | |||||
| 12-13 | |||||
| 13-14 | |||||
| 14-15 | |||||
| 15-16 | |||||
| 16-17 | |||||
| 17-18 | |||||
| 18-19 | |||||
| 19-20 | |||||
| 20-21 | |||||
| 21-22 |
Légendes:
Lecture
Exercise, TP
Project, other