Pharmacology and pharmacokinetics
Summary
This course introduces the student to the fudamentals of pharmacology, pharmacokinetics and drug-receptor interactions. It discusses also pharmacogenetics and chronopharmacology, to exemplify the challenges of personalized medicine.
Content
- Introduction to Pharmacology and general topics of pharmacology
- Pharmacokinetics: principal models and parameters, Drug Absorption, Distribution, Metabolism and Excretion (ADME)
- Chronopharmacology: effect of circadian rhythm on drug action.
- Pharmacogenetics: candidate genes for variable drug response.
- Pharmacodynamics: Drug-target interaction, quantitative description of ligand binding, relationship between ligand binding and functional effect, antagonism; exercises
- Classes of drug targets: functional and structural aspects, strategies of drug targeting; examples
- General topics of pharmacotherapy
Keywords
Pharmacokinetics
Pharmacodynamics
Absorption
Distribution
Drug metabolism
drug elimination
Drug
Pharmacogenetics
Chronopharmacology
Learning Prerequisites
Required courses
General human physiology
Recommended courses
Cellular and molecular physiology
Biochemistry
Maths
Important concepts to start the course
Bachelor in Life Sciences and Technology or equivalent, i.e. physiology, cell and molecular biology, maths
Learning Outcomes
By the end of the course, the student must be able to:
- Describe mechanisms of Drug Absorption, Distribution, Metabolism and Excretion (ADME)
- Describe principal models and parameters of pharmacokinetics
- Explain the role of genetic polymorphisms in variable drug response
- Describe the effect of circadian rhythms on drug action
- Describe the basic principles of pharmacodynamics
- Compute and represent graphically the concentration dependence of agonist and agonist effects and of ligand binding, and the kinetics of drug action
- Describe the principles of drug action on the main classes of drug targets and illustrate it with examples
- Describe the principles of gene therapy and protein therapeutics and illustrate it with examples
Teaching methods
Ex Cathedra and exercises
Assessment methods
written exam
Supervision
| Office hours | Yes |
| Assistants | No |
| Forum | No |
Resources
Bibliography
Handouts will be placed on the moodle site of the course.
Most of the topics are covered in the following reference textbooks:
- "Rang and Dale's pharmacology " by James Ritter et al., Elsevier/Churchill Livingstone, 9th edition, 2018
- "Principles of Pharmacology" by DE Golan et al., Lippincott Williams & Wilkins, 4th edition, 2016.
- "Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications" by Hartmut Derendorf, Stephan Schmidt, 5th edition, 2019.
Ressources en bibliothèque
- Ritter. Rang and Dale's pharmacology
- Golan. Principles of Pharmacology
- Derendorf. Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications
Moodle Link
Dans les plans d'études
- Semestre: Printemps
- Forme de l'examen: Ecrit (session d'été)
- Matière examinée: Pharmacology and pharmacokinetics
- Cours: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel
- Semestre: Printemps
- Forme de l'examen: Ecrit (session d'été)
- Matière examinée: Pharmacology and pharmacokinetics
- Cours: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel
- Semestre: Printemps
- Forme de l'examen: Ecrit (session d'été)
- Matière examinée: Pharmacology and pharmacokinetics
- Cours: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel