BIO-478 / 2 credits

Teacher(s): Kellenberger Stephan Beat, Firsov Dmitri

Language: English


Summary

This course introduces the student to the fudamentals of pharmacology, pharmacokinetics and drug-receptor interactions. It discusses also pharmacogenetics and chronopharmacology, to exemplify the challenges of personalized medicine.

Content

Keywords

Pharmacokinetics

Pharmacodynamics

Absorption

Distribution

Drug metabolism

drug elimination

Drug

Pharmacogenetics

Chronopharmacology

 

Learning Prerequisites

Required courses

General human physiology

Recommended courses

Cellular and molecular physiology

Biochemistry

Maths

Important concepts to start the course

Bachelor in Life Sciences and Technology or equivalent, i.e. physiology, cell and molecular biology, maths

Learning Outcomes

By the end of the course, the student must be able to:

  • Describe mechanisms of Drug Absorption, Distribution, Metabolism and Excretion (ADME)
  • Describe principal models and parameters of pharmacokinetics
  • Explain the role of genetic polymorphisms in variable drug response
  • Describe the effect of circadian rhythms on drug action
  • Describe the basic principles of pharmacodynamics
  • Compute and represent graphically the concentration dependence of agonist and agonist effects and of ligand binding, and the kinetics of drug action
  • Describe the principles of drug action on the main classes of drug targets and illustrate it with examples
  • Describe the principles of gene therapy and protein therapeutics and illustrate it with examples

Teaching methods

Ex Cathedra and exercises

Assessment methods

Written exam

Supervision

Office hours Yes
Assistants No
Forum No

Resources

Bibliography

Handouts will be placed on the moodle site of the course.
Most of the topics are covered in the following reference textbooks:

  • "Rang and Dale's pharmacology " by James Ritter et al., Elsevier/Churchill Livingstone, 9th edition, 2018
  • "Principles of Pharmacology" by DE Golan et al., Lippincott Williams & Wilkins, 4th edition, 2016.
  • "Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications" by Hartmut Derendorf, Stephan Schmidt, 5th edition, 2019.

 

In the programs

  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Pharmacology and pharmacokinetics
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Pharmacology and pharmacokinetics
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Pharmacology and pharmacokinetics
  • Lecture: 2 Hour(s) per week x 14 weeks

Reference week

 MoTuWeThFr
8-9     
9-10     
10-11     
11-12     
12-13     
13-14     
14-15     
15-16     
16-17     
17-18     
18-19     
19-20     
20-21     
21-22