Integrative structural biology for Life sciences
BIO-643 / 2 crédits
Enseignant(s): Abriata Luciano Andres, Duhoo Yoan Désiré, Krebs Anna-Sophia, Lau Kelvin Ka Ching, Pojer Florence, Schneider Jonathan
Langue: Anglais
Remark: Registration via edms@epfl.ch
Frequency
Every 2 years
Summary
Hands-on course in Biomolecular Integrative Structural Biology by SV experts in the field of X-ray crystallography, cryo-Electron Microscopy, Bio-NMR and protein modeling tools. No previous knowledge in Structural Biology or Bioinformatics is required.
Content
The course will start on 11th September and end on 18th December 2025. It will take place every Thursday from 15h00 to 17h00 in room AI 3142. This course will teach how to interpret data from major structural biology techniques and connect experimental approaches to computational modeling. You will have sessions that are tutorial based on the main structural biology software as an introduction to data processing workflows.
Topics discussed in class are expected to include:
- Modeling tools for proteins, such as alphafold; and integration with experimental data
- Single Particle Cryo-Electron Microscopy
- Macromolecular X-ray crystallography
- Bio-NMR
Other topics may be included as needed.
Visit of structural Biology Core Facilities within EPFL will be proposed.
Note
Please bring your own laptop and mouse. Course open to max. 16 students.
Keywords
Macromolecular X-ray crystallography, Modeling and molecular dynamic of proteins, Single Particle Cryo-Electron Microscopy, Bio-NMR, Mass Spectrometry applied to Structural Biology.
Learning Prerequisites
Required courses
Basic knowledge in molecular biology
Learning Outcomes
- Interpret data generated from major structural biology techniques
- Integrate computational modeling in your research
Teaching methods
Lectures and hands-on sessions will be presented by experts from EPFL and in the Lemanic region.
Assessment methods
Oral presentation on a specific subject within the field at the end of the course.
Resources
Websites
Moodle Link
Dans les plans d'études
- Nombre de places: 12
- Forme de l'examen: Exposé (session libre)
- Matière examinée: Integrative structural biology for Life sciences
- Cours: 12 Heure(s)
- Exercices: 12 Heure(s)
- TP: 6 Heure(s)
- Type: optionnel
- Nombre de places: 12
- Forme de l'examen: Exposé (session libre)
- Matière examinée: Integrative structural biology for Life sciences
- Cours: 14 Heure(s)
- Exercices: 14 Heure(s)
- TP: 6 Heure(s)
- Type: optionnel