Coursebooks

The making of an innovative medicine

BIO-698

Lecturer(s) :

Clerc Roger G.

Language:

English

Frequency

Every year

Remarque

Next time Fall 2019

Summary

To expose participants to translational research (from bench to bedside and back) and drug discovery

Content

Through a logical series of presentations both from the participants and the lecturer (flipped classroom format, oral presentations, workshops) on the making of an innovative medicine, the entire and complex process starting from the therapeutic target identification up until the clinical development and use in clinical practice of a new molecular entity (NME) will be addressed and discussed.

The course is divided in twelve sections of each 2 periods of 45 minutes :

Section 1 Scope of the course, general organization, case study

Section 2 Historical perspective: the modern pharmacy

Section 3 Introduction to translational research: crossing the bridge

Section 4 Therapeutic target identification I & II

Section 5 Structure based drug design, medicinal chemistry, low/high throughput screening assays, multiple paralell parameters optimization MDO

Section 6 Therapeutic peptides and biologicals: today's - tomorrow's pharmacy

Section 7 Personalized Healthcare (PHC) precision medicine

Section 8 Pharmacogenetic polymorphisms, Pharmacogenomics

Section 9 In vivo pharmacology, investigative toxicology

Section 10 Clinical research, phase 0, phase I, II, III, IV

Section 11 Health Hackathon - Hacking medicine I

Section 12 Health Hackathon - Hacking medicine II

Minimum 4 participants

Maximum 25 participants

Keywords

Translational biomedical research/Drug discovery

Learning Prerequisites

Required courses

Basic Molecular Biology, Cellular Signaling, Pharmacology

Resources

Bibliography

¿A prescription for change : the looming crisis in drug development¿ Pr M. Kinch UNC Press(2017) ISBN 978-1-4696-3062-5