Biomedical optics

Summary

This course addresses the principles governing the interactions between light and biological tissue, their optical properties and basic concepts of radiometry. Illustrative diagnostic and therapeutic applications of light in medicine and photobiology will also be described.

Content

Keywords

Biomedical photonics, tissue optics, light-tissue interactions, photodiagnosis, phototherapy, light dosimetry, dyes, photosensitizers.

Learning Prerequisites

Important concepts to start the course

Basic background in biology, chemistry and optics.

Learning Outcomes

• Design simple systems used for phototherapy and photodiagnosis.
• Characterize the spectral design of apparatus used in biomedical optics.
• Compute the light dose in biological tissues.
• Identify the optical components to develop an apparatus used in phototherapy.
• Explain the working principles of apparatus used in biomedical optics.
• Model the propagation of light in biological tissues.
• Quantify the light dose in phototherapy.
• Interpret data obtained or published in photomedicine.
• Design simple systems used for phototherapy and photodiagnosis.
• Characterize the spectral design of apparatus used in biomedical optics.
• Compute the light dose in biological tissues.
• Identify the optical components to develop an apparatus used in phototherapy.
• Explain the working principles of apparatus used in biomedical optics.
• Model the propagation of light in biological tissues.
• Quantify the light dose in phototherapy.
• Interpret data obtained or published in photomedicine.

Transversal skills

• Access and evaluate appropriate sources of information.
• Collect data.
• Make an oral presentation.
• Summarize an article or a technical report.
• Communicate effectively with professionals from other disciplines.

Teaching methods

Lectures, Exercises, recent literature review papers, classroom discussion + oral presentation.

Expected student activities

Exercises, lecture of review papers, classroom discussion + oral presentation.

Assessment methods

Oral exam (1/2) + presentation (3/8) + exercices (1/8).

Supervision

Resources

Bibliography

• Optics / Hecht EBOOK
• Optics / Hecht
• Optical-Thermal Response of Laser Irradiated Tissue / Welch
• Photosensitisers in Biomedicine / Wainwright
• Optics / Hecht
• Handbook of Photomedicine / Hamblin
• Quantitative Biomedical Optics / Bigio
• Handbook of Biomedical Fluorescence / Mycek
• Principles of Fluorescence Spectroscopy / Lakowicz

Ressources en bibliothèque

• Optics / Hecht
• Optical-Thermal Response of Laser Irradiated Tissue / Welch
• Handbook of Photomedicine / Hamblin
• Principles of Fluorescence Spectroscopy / Lakowicz
• Photosensitisers in Biomedicine / Wainwright
• Quantitative Biomedical Optics / Bigio
• Handbook of Biomedical Fluorescence / Mycek

Notes/Handbook

Slides available on Moodle.

Moodle Link

• https://go.epfl.ch/BIOENG-445

Prerequisite for

Master. Academic research and R/D activities in the industry of this field