Total synthesis of natural products
Summary
Complex polycyclic natural products are chosen to illustrate the evolution of the state-of-the-art of the field, the interplay between strategy and new reactions as well as the importance of implementing multi-bond forming processes in a synthesis.
Content
Retro-synthesis and synthesis of different classes of natural products important for their structure and/or bioactivity.
Keywords
Retro-synthetic analysis, Synergism between strategy and new reactions, Domino reactions, multicomponent reactions, Oxidative coupling, Pattern Recognition, Hidden Symmetry, C-H Functionalization, Asymmetric organocatalysis
Learning Prerequisites
Recommended courses
General knowledge of organic reactions. Basic knowledge of retro-syntheis. EPFL lectures fonctions et réactions organiques I and II, synthèse asymétrique, target synthesis, structure and reactivity or equivalent courses.
Learning Outcomes
By the end of the course, the student must be able to:
- Draw reaction mechanism
- Analyze synthetic route
- Elaborate synthetic scheme
- Design synthetic strategy
Supervision
| Office hours | Yes |
| Assistant.e.s | Yes |
| Forum | Yes |
Resources
Ressources en bibliothèque
Websites
Moodle Link
In the programs
- Semester: Fall
- Exam form: Written (winter session)
- Subject examined: Total synthesis of natural products
- Courses: 2 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Written (winter session)
- Subject examined: Total synthesis of natural products
- Courses: 2 Hour(s) per week x 14 weeks
- Type: optional
- Exam form: Written (winter session)
- Subject examined: Total synthesis of natural products
- Courses: 2 Hour(s) per week x 14 weeks
- Type: optional