Fundamentals of biosensors and electronic biochips

EE-515 / 3 credits

Teacher: Guiducci Carlotta

Language: English

Withdrawal: It is not allowed to withdraw from this subject after the registration deadline.

Summary

The labels "biosensor"€ and "eBiochip" have been employed to refer to the most diverse systems and in several fields of application. The course is meant not only to provide means to dig into this sea but also a thoughtful understanding of the detection principles and a design perspective.

Content

PART I Fundamentals

§Ch 0 Laying the foundations.

§More definitions (assay, diagnostics, …); §Parameters qualifying a sensor.

§Ch 1 Possible configurations of a biosensing system. 

§Area confined and surface confined. §Miniaturization consequences

§Ch 2 The solid/liquid interface

§Electrical properties §Optical properties §Surface chemistry to make a surface sense. Specificity 

§Ch 3 Systems working in dynamic regime  

§Sensors in flow chambers or in channels §Large consequences of going Nano

PART 2 Detection principles and analysis

§ Detection principles

§Charge transfer § Probing interface electrical parameters § Probing interface optical parameters § Characterizing mass change on a surface § Perturbation of electrical field in hybrid electron devices (transistor)

§Case studies of micro/nanosensors and high throughput systems

Learning Prerequisites

Recommended courses

Understanding Statistics and Experimental Design 

Related courses:

BioMEMS

Bioanalytics and analytical sensors

 

Important concepts to start the course

The course is hystorically addressed to students with many sorts of background.

When needed, the premises for the understanding of certain topics are outlined and discussed during the course.

In particular, the course would require some familiarity with the fundamentals of molecular biology and a solid physics background. 

Instrumental prerequisites that span from electrode/solution interfaces, to binding kinetics, to electrical characterization of biological elements, to microelectronic proccesses are recalled and integrated in the course material. 

Teaching methods

§3 credits

§2/3 Frontal lecture.

1/3 exercises 

Expected student activities

§Come to classes

§Study assigned material 

§Prepare exercise before the session

Assessment methods

 

§Written exam (end of the semester)

 

Supervision

Others office hours on appointment 

Resources

Bibliography

A selection of chapters from the books listed below is proposed to explore some topics and deepen understanding. The list is non exhaustive of the concerned literature and does not cover the entire content of the course that is supported by the slides and by selected scientific journal papers. 

Bioelectronics handbook, M. Grattarola, G. Massobrio, Ms Graw Hill - (Part 2, Ch 8, Ch 9 Ch 10)

Intermolecular and Surface Forces, J. Israelachvili, Academic press, (in particular Ch 12)

Surface Design: Applications in Bioscience and Nanotechnology, R. Forch, H. Schonherr, A.T. Jenkins, Wiley, (Ch 1, Ch 3.3, App F)

Bioelectronics, I. WIllner, E. Katz, Wiley-VCH, (Ch 5, Ch 8)

Handbook fo Surface Plasmon Resonance, RBM Scasfoort, A. Tudos, RSC, (Ch 1, Ch 4, Ch 5)

 

Ressources en bibliothèque

Notes/Handbook

The course material is made available on the moodle.

Moodle Link

In the programs

  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Number of places: 70
  • Exam form: Written (winter session)
  • Subject examined: Fundamentals of biosensors and electronic biochips
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Type: optional

Reference week

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