Bio-nano-chip design

EE-517 / 4 credits

Teacher: Carrara Sandro

Language: English

Summary

Introduction to heterogeneous integration for Nano-Bio-CMOS sensors on Chip. Understanding and designing of active Bio/CMOS interfaces powered by nanostructures.

Content

Currents and capacitive-effects in water solutions

Introduction to biological molecules

Thermodynamics of molecular Interactions

Nanotechnology for molecular assembly on chip surfaces

Nanotechnology to prevent electron transfer

Nanotechnology to enhance electron transfer

Chip design for electrochemical sensing: basic configurations

Chip design for biosensing with label-free capacitance mode (CBCM & FTCM Methods)

Chip design for biosensing in constant-bias (Current-to-Voltage & FTCC Methods)

Chip design for biosensing in voltage-scan (VDCM & DDSM Methods)

Keywords

OpAmp, CMOS, biosensors, carbon nanotubes, alkane/silane thiols, proteins, DNA

Learning Prerequisites

Recommended courses

Electronics I (BS course)

General chemistry OR Chemistry of surfaces (both BS courses)

Analysis IV (BS course)

Learning Outcomes

By the end of the course, the student must be able to:

  • Choose bio materials
  • Choose nano materials
  • Judge an electrical interface
  • Design complex analog circuits for electrochemical biosensing
  • Design Bio-Nano-CMOS-sensing devices at system level
  • Realize and discuss nanotechnology and molecular layers on chip Investigate
  • Discuss biotechnology to Realize biosensors on chip

Teaching methods

Ex cathedra, exercises, and group-project with the help of Teaching Assistants

Expected student activities

Following the ex-cathedra lectures, active participation to the Q/A sessions organize during the ex-cathedra lectures, home work on lectures' slides as well as on the proposed excercies, work in class as well as at home on the group project.

Assessment methods

Written exam and group-project report

Resources

Bibliography

  1. Course slides
  2. Book: S.Carrara, Bio/CMOS Interfaces and Co-Design, Springer, NY, 2013
  3. Book: S.Carrara, Bio/CMOS Interfaces and Co-Design, 2nd edition, Springer, NY, 2024

Ressources en bibliothèque

Notes/Handbook

https://link.springer.com/book/10.1007/978-1-4614-4690-3 (1st Edition, 2013)
https://link.springer.com/book/10.1007/978-3-031-31832-0 (2nd Edition, 2024, 4 more chapters, and 5 more appendixes)

Websites

Moodle Link

In the programs

  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Bio-nano-chip design
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Bio-nano-chip design
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Bio-nano-chip design
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Bio-nano-chip design
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Bio-nano-chip design
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Bio-nano-chip design
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Bio-nano-chip design
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Bio-nano-chip design
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Bio-nano-chip design
  • Courses: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Type: optional

Reference week

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