Structural analysis
CH-314 / 4 crédits
Enseignant(s): Bostedt Christoph, Boyarkine Oleg, Emsley David Lyndon
Langue: Anglais
Summary
The aim of this course is to treat three of the major techniques for structural characterization of molecules: mass spectrometry, NMR, and X-ray techniques.
Content
Weeks 1-5: Mass Spectrometry (Prof. Rizzo)
- Introduction to mass spectrometry
- Masses of elements and molecules
- Isotopes and isotope distributions
- Figures of merit: mass accuracy and resolution
- Mass spectrometry instrumentation: Ion sources, mass analyzers, and detectors
- Tandem MS
- Ion mobility MS
- Combining MS with IR spectroscopy for molecular identification
Weeks 6-10: NMR (Prof. Emsley)
- Principles of nuclear magnetism
- Quantum description of magnetic resonance leading to the vector model
- Interactions defining the spectrum: chemical shifts, scalar, dipolar and quadrupolar couplings
- Time-domain spectroscopy by pulsed excitation: interaction with radiofrequency fields, coherence, precession, signal induction and the Fourier Tranform
- Relaxation and the return to equilibrium
- Polarization transfer
- Multi-dimensional correlation spectroscopy
Weeks (11-14): X-ray (Prof. Bostedt)
- Introduction to x-rays and x-ray sources
- X-ray properties of the elements
- Diffraction and refraction
- Scattering and imaging
- X-ray spectroscopy
Keywords
Spectroscopy; Mass Spectrometry; Magnetic Resonance; NMR; X-Rays; Diffraction; Strucutre; Chemical Analysis;
Learning Outcomes
By the end of the course, the student must be able to:
Transversal skills
- Access and evaluate appropriate sources of information.
- Set objectives and design an action plan to reach those objectives.
Assessment methods
Written Examination
Dans les plans d'études
- Semestre: Automne
- Forme de l'examen: Ecrit (session d'hiver)
- Matière examinée: Structural analysis
- Cours: 3 Heure(s) hebdo x 14 semaines
- Exercices: 1 Heure(s) hebdo x 14 semaines
- Semestre: Automne
- Forme de l'examen: Ecrit (session d'hiver)
- Matière examinée: Structural analysis
- Cours: 3 Heure(s) hebdo x 14 semaines
- Exercices: 1 Heure(s) hebdo x 14 semaines
- Semestre: Automne
- Forme de l'examen: Ecrit (session d'hiver)
- Matière examinée: Structural analysis
- Cours: 3 Heure(s) hebdo x 14 semaines
- Exercices: 1 Heure(s) hebdo x 14 semaines
Semaine de référence
| Lu | Ma | Me | Je | Ve | |
| 8-9 | |||||
| 9-10 | |||||
| 10-11 | |||||
| 11-12 | |||||
| 12-13 | |||||
| 13-14 | |||||
| 14-15 | |||||
| 15-16 | |||||
| 16-17 | |||||
| 17-18 | |||||
| 18-19 | |||||
| 19-20 | |||||
| 20-21 | |||||
| 21-22 |
Légendes:
Cours
Exercice, TP
Projet, autre