Photomedicine

Summary

The most important clinical diagnostic and therapeutic applications of light will be described. In addition, this course will address the principles governing the interactions between light and biological tissues, their optical properties and basic concepts in photobiology and photochemistry.

Content

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Keywords

Photomedicine, tissue optics, photobiology, photochemistry, light-tissue interactions, photodiagnosis, phototherapy, light dosimetry, dyes, photosensitizers.

Learning Prerequisites

Important concepts to start the course

Basic background in biology, chemistry and optics.

Learning Outcomes

• Define the spectral design of apparatus used in biomedical optics.
• Compute the light dose in biological tissues.
• Identify the optical components to develop an apparatus used in photodetection and phototherapy.
• Describe the working principles of apparatus used in biomedical optics.
• Model the propagation of light in biological tissues.
• Interpret data obtained or published in the field of photomedicine.
• Describe the photobiological and photochemical mechanisms involved in photomedicine.

Transversal skills

• Communicate effectively with professionals from other disciplines.
• Access and evaluate appropriate sources of information.
• Write a scientific or technical report.
• Write a literature review which assesses the state of the art.
• Summarize an article or a technical report.
• Demonstrate the capacity for critical thinking

Teaching methods

Lectures, Exercises performed during the courses, recent literature review papers, classroom discussion + oral presentation.

Expected student activities

Exercises, lecture of review papers, classroom discussion + oral presentation.

Assessment methods

Oral exam (2/3) + oral presentation (1/3).

Supervision

Office hours	Yes
Assistants	No
Forum	No

Resources

Bibliography

- Optical-Thermal Response of Laser Irradiated Tissue, A.J. Welch & M.J.C. van Gemert (Plenum, 1995).

 

- Principles of Fluorescence Spectroscopy, J.R. Lakowicz (Kluwer, 1999).

 

- Optics, E. Hecht (Addison Wesley, 2000).

 

- Handbook of Photomedicine, M. Hamblin & Y.-Y. Huang (CRC Press, 2013).

 

- Handbook of Biomedical Fluorescence, M.-A. Mycek & B. W. Pogue (Dekker, 2003).

- Photosensitizers in Biomedicine, M. Wainwright (Wiley-Blackwell, 2009).

- Quantitative Biomedical Optics, I. Bigio & S. Fantini (Cambridge Univ. Press, 2016).

Ressources en bibliothèque

• Optical-thermal response of laser-irradiated Tissue / Welch
• Optics / Hecht
• Handbook of photomedicine / Hamblin
• Principles of fluorescence spectroscopy / Lakowicz
• Handbook of biomedical fluorescence / Mycek
• Photosensitizers in biomedicine / Wainwright
• Quantitative biomedical optics / Bigio

Notes/Handbook

Slides available on Moodle.

Websites

• https://www.epfl.ch/labs/lifmet/wagnieres/
• http://people.epfl.ch/georges.wagnieres?lang=en&cvlang=en
• http://www.opticsinfobase.org/vjbo/virtual_issue.cfm
• http://www.photobiology.info

Moodle Link

• https://go.epfl.ch/CH-448

Prerequisite for

Master. Academic research and R/D activities in the industry of this field