Neuroscience: from molecular mechanisms to disease
BIO-480 / 5 crédits
Enseignant(s): Gräff Johannes, Mahul Mellier Anne-Laure, Schneider Bernard
Langue: Anglais
Summary
The goal of the course is to guide students through the essential aspects of molecular neuroscience and neurodegenerative diseases. The student will gain the ability to dissect the molecular basis of disease in the nervous system in order to begin to understand and identify therapeutic strategies.
Content
- Anatomical and functional organization of the brain
- Unique biology of neurons
- Unique biology of glial cells
- Generation, survival and integration of nerve cells
- Synapse formation, regeneration and plasticity
- Neuropharmacology
- Alzheimer's disease
- Parkinson's disease
- Motor neuron diseases
- Prion diseases
- Polyglutamine expansion diseases
- Protein aggregation in neurodegenerative disease
- Animal models of disease and translational neuroscience
- Neuroepigenetics
Learning Prerequisites
Important concepts to start the course
Understanding of molecular and cellular biology.
Learning Outcomes
By the end of the course, the student must be able to:
- Define key concepts in neurodegenerative diseases
- Assess / Evaluate novel therapeutic strategies for neurodegenerative diseases
- Compare the unique properties of neuronal and glial cells
- Hypothesize therapeutic strategies for treating brain diseases
- Describe the function of genes associated with neurodegenerative diseases
- Design experiments to evaluate genetic mutations associated with neurodegenerative diseases
- Define key concepts in neurodegenerative diseases
- Assess / Evaluate novel therapeutic strategies for neurodegenerative diseases
- Compare the unique properties of neuronal and glial cells
- Hypothesize therapeutic strategies for treating brain diseases
- Describe he function of genes associated with neurodegenerative diseases
- Design experiments to evaluate genetic mutations associated with neurodegenerative diseases
Transversal skills
- Access and evaluate appropriate sources of information.
- Summarize an article or a technical report.
Assessment methods
Written exam. 3 hours duration. Will contain short essay-style questions.
Resources
Bibliography
Purves, Neuroscience. 2012. 5th Ed. Sinauer Associates
Kandel, Principles of Neural Science. 2012. 5th Ed. McGraw Hill
Ressources en bibliothèque
Ressources en bibliothèque
- Kandel, Principles of Neural Science. 2012. 6th Ed. McGraw Hill
- Purves, Neuroscience. 2012. 5th Ed. Sinauer Associates
Moodle Link
Dans les plans d'études
- Semestre: Automne
- Forme de l'examen: Ecrit (session d'hiver)
- Matière examinée: Neuroscience: from molecular mechanisms to disease
- Cours: 3 Heure(s) hebdo x 14 semaines
- Exercices: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel
- Semestre: Automne
- Forme de l'examen: Ecrit (session d'hiver)
- Matière examinée: Neuroscience: from molecular mechanisms to disease
- Cours: 3 Heure(s) hebdo x 14 semaines
- Exercices: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel
- Semestre: Automne
- Forme de l'examen: Ecrit (session d'hiver)
- Matière examinée: Neuroscience: from molecular mechanisms to disease
- Cours: 3 Heure(s) hebdo x 14 semaines
- Exercices: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel
- Semestre: Automne
- Forme de l'examen: Ecrit (session d'hiver)
- Matière examinée: Neuroscience: from molecular mechanisms to disease
- Cours: 3 Heure(s) hebdo x 14 semaines
- Exercices: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel
- Semestre: Automne
- Forme de l'examen: Ecrit (session d'hiver)
- Matière examinée: Neuroscience: from molecular mechanisms to disease
- Cours: 3 Heure(s) hebdo x 14 semaines
- Exercices: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel
- Semestre: Automne
- Forme de l'examen: Ecrit (session d'hiver)
- Matière examinée: Neuroscience: from molecular mechanisms to disease
- Cours: 3 Heure(s) hebdo x 14 semaines
- Exercices: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel
- Forme de l'examen: Ecrit (session d'hiver)
- Matière examinée: Neuroscience: from molecular mechanisms to disease
- Cours: 3 Heure(s) hebdo x 14 semaines
- Exercices: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel