BIO-615 / 2 crédits
Every 2 years
Animals must learn from past experiences, to adapt their behavior to an ever-changing environment. Students will learn about the neuronal circuit mechanisms of reward-based learning, and of aversively-mediated learning, by studying the current scientific literature on these topics.
- Behavioral techniques, recording techniques, as well as circuit tracing and optogenetic approaches to study associative learning in rodents and monkeys
- Definition of reward, aversion, valence, conditioned stimulus (CS) and unconditioned stimulus (US)
- The crucial role of midbrain dopamine neurons in reward learning
- Synaptic inputs and outputs of a midbrain dopaminergic area
- Dopamine control of plasticity at excitatory synapses
- Acetylcholine signals for reinforcement learning
- Fear conditioning as a model for aversively-motivated learning
- Plasticity at excitatory synapses in the basolateral amygdala (BLA) as a substrate for fear learning
- Representation of signals with both positive and negative valence in the BLA
- In-vivo imaging of changes in the neuronal population response to a CS during fear learning
- What drives aversively-motivated learning? - a representation of painful stimuli via glutamatergic connections and/or neuromodulatory systems?
Time: Thursdays 9:00 - 11:00 - from 23rd September (Week 1) to 4th November (Week 7) (first half of semester)
Thereafter, Wednesdays 9:00 - 11:00 - from 10th November (Week 8) to 22nd December (Week 14) (second half of semester)
By the end of this course, students should be able to critically assess the scientific literature that analyzes neuronal circuits in associative learning.
Mouse behavior, reward, aversion, fear, valence, associative learning, neuronal circuits, optogenetics, in-vivo recording of neuronal activity, circuit mapping, conditioned stimulus, unconditioned stimulus.
'Neuroscience: cellular and circuit mechanisms (BIO-482)' or equivalent
- Published papers available online / in the EPFL library
- additional materials will be handed out when relevant
Dans les plans d'études
- Nombre de places: 12
- Forme de l'examen: Pendant le semestre (session libre)
- Matière examinée: Neural circuits for reward and aversion learning
- Cours: 4 Heure(s)
- Exercices: 52 Heure(s)