Dynamics of biomolecular processes
Summary
In this course we will discuss advanced biophysical topics, building on the framework established in the course "Macromolecular structure and interactions". The course is held in English.
Content
- Membranes
- fusion, fission, membrane deformation
- diffusion
- Channels and receptors
- ion channels, receptors
- detection of physical and chemical stimuli
- Protein folding / substates / dynamics
- molecular chaperones and protein folding in the cell
- conformational fluctuations in protein function and regulation
- natively disordered proteins
- Protein machines
- motor proteins in trafficking
- motor proteins in DNA and chromatin transactions
- DNA binding proteins / transcription
- protein DNA interactions
- search processes in the nucleus
- dynamics and function of the transcription machinery
Keywords
protein folding, dynamics, molecular machines, DNA, transcription, receptors, membrane, diffusion, trafficking
Learning Prerequisites
Required courses
Macromolecular structure and interactions
Chemical Biology
Chemical thermodynamics
Recommended courses
Chemical Biology
Important concepts to start the course
Protein structure, folding, function and dynamics
Theoretical biophysics, thermodynamics, chemical kinetics
Membranes and lipids
Teaching methods
Ex cathedra and discussions.
Expected student activities
Literature study
Active participation to discussions
Assessment methods
Written exam
Supervision
| Others |
Resources
Bibliography
Literature articles / reviews
"Principles of Physical Biochemistry", Van Holde, Prentice Hall
"Physical Biology of the Cell", Phillips, Kondev, Theriot, Garcia, Garland Science
Ressources en bibliothèque
Moodle Link
Prerequisite for
CH-413 Nanobiotechnology and Biophysics
CH-419 Cellular Signalling
Dans les plans d'études
- Semestre: Printemps
- Forme de l'examen: Ecrit (session d'été)
- Matière examinée: Dynamics of biomolecular processes
- Cours: 2 Heure(s) hebdo x 14 semaines
- Type: obligatoire
- Semestre: Printemps
- Forme de l'examen: Ecrit (session d'été)
- Matière examinée: Dynamics of biomolecular processes
- Cours: 2 Heure(s) hebdo x 14 semaines
- Type: optionnel