Catalytic asymmetric reactions in organic chemistry
Summary
This lecture presents the development of catalytic asymmetric reactions in organic chemistry, including important current topics of research in the field.
Content
Principles and Methods of Catalysis:
1. Asymmetric activation of electrophiles with Lewis and Bronsted acids.
2. Asymmetric activation of nucleophiles with metal-and organo-catalysts.
3. Dual activation with acid-base, metal-base, metal-metal and single metal systems.
4. Umpolung of reactivity.
Learning Prerequisites
Recommended courses
General master level knowledge in organic chemistry is highly recommended (including EPFL lectures organic reactions and fonctions I-III, asymmetric synthesis, retrosynthesis, structure and reactivity, or similar lectures in other institutions). Basic knowledge in organometallic chemistry is also recommended.
Learning Outcomes
By the end of the course, the student must be able to:
- Elaborate on the concepts of catalysis an stereoinduction described in a recent publication
- Formulate in details the following points in a publication: type of reaction, principle of reactivity, catalytic activation and asymmetric induction, full catalytic cycle
- Critique the content of a recent publication in the context of the knowledge in the field
Transversal skills
- Access and evaluate appropriate sources of information.
- Make an oral presentation.
- Summarize an article or a technical report.
- Take feedback (critique) and respond in an appropriate manner.
- Communicate effectively, being understood, including across different languages and cultures.
Teaching methods
ex cathedra presentation with summary and litterature presentations by the students
Expected student activities
active participation to the lecture
presentation of summaries of the course
oral presentation on recent publications in the field
Assessment methods
Oral exam of 20 min, with 20 min preparation (recent publication) for 80% of the grade
Two oral presentations during the lecture counting for 20% of the grade.
Supervision
Office hours | No |
Assistants | Yes |
Forum | Yes |
Resources
Virtual desktop infrastructure (VDI)
No
Bibliography
power point presentation without details, need to be completed during lecture (the students will receive the slides in advance)
Dans les plans d'études
- Semestre: Printemps
- Forme de l'examen: Oral (session d'été)
- Matière examinée: Catalytic asymmetric reactions in organic chemistry
- Cours: 2 Heure(s) hebdo x 14 semaines
- Semestre: Printemps
- Forme de l'examen: Oral (session d'été)
- Matière examinée: Catalytic asymmetric reactions in organic chemistry
- Cours: 2 Heure(s) hebdo x 14 semaines
- Forme de l'examen: Oral (session d'été)
- Matière examinée: Catalytic asymmetric reactions in organic chemistry
- Cours: 2 Heure(s) hebdo x 14 semaines