Coursebooks

State-of-the-Art Topics in Neuroscience Vlll: Fear Learning: from neuronal circuits to translation

BIO-693(8)

Lecturer(s) :

Gräff Johannes
Sandi Perez Maria del Carmen
Schneggenburger Ralf

Language:

English

Frequency

Every year

Remarque

Next time: Fall 2019

Summary

Anxiety disorders are widespread in the human population. At the same time, the behavioral paradigm of fear learning offers researchers a platform to investigate the neuronal circuit basis of emotionally motivated learning behaviors, exploiting state-of-the-art optic- and genetic approaches in mice.

Content

Anxiety disorders are widespread in the human population. At the same time, the behavioral paradigm of fear learning offers researchers a platform to investigate the neuronal circuit basis of emotionally motivated learning behaviors, exploiting state-of-the-art optic- and genetic approaches in mice. Understanding the fundamental molecular, cellular- and circuit mechanisms of fear learning will form the basis for an improved treatment of anxiety in the future.

The PhD students will actively participate in the Symposium with questions and discussion participation. As a control that the students have reached the learning aims of the course, PhD students will summarize a presentation of their choice during a final 3h block session under the supervision of the course instructors.

MONDAY 25th NOVEMBER 2019

Session 1 Mechanisms of fear learning: amygdala circuits

Chair: Ralf Schneggenburger

09:00 ¿ 09:30 Andreas Lüthi (FMI, Basel, CH)

Adaptive disinhibitory gating permits associative learning

09:30 ¿ 09:40 Discussion

09:40 ¿ 10:10 Bo Li (Cold Spring Harbor, USA)

Amygdala circuits in motivated behaviors

10:10 ¿ 10:20 Discussion

10:20 ¿ 10:35 Short Talk 1

10:35 ¿ 10:40 Discussion

11:10 ¿ 11:40 Sheena Josselyn (University of Toronto, CDN, Toronto, Canada)

Making, Breaking and Linking Memories in Mice

11:40 ¿ 11:50 Discussion

11:50 ¿ 12:20 Wulf Haubensak (IMP, Wien, Austria)

Assembling affective states by amygdala hierarchical interactions

12:20 ¿ 12:30 Discussion

12:30 ¿ 14:00 Lunch & Poster Session

Session 2 Beyond the amygdala: circuits of fear and pain involved in learning

Chair: Johannes Gräff

14:00 ¿ 14:30 Cyril Herry (Neurocentre Magendie, Bordeaux, France)

Dynamic prefrontal population coding of value and action during aversive learning

14:30 ¿ 14:40 Discussion

14:40 ¿ 15:10 Nadine Gogolla (MPI für Neurobiologie, Munich,Germany)

Regulation of fear and anxiety through insular cortical circuits

15:10 ¿ 15:20 Discussion

15:20 ¿ 15:35 Short Talk 2

15:35 ¿ 15:40 Discussion

15:40 ¿ 16.10 Coffee break

16:10 ¿ 16:40 Rohini Kuner (University of Heidelberg, Germany)

Fear and Pain: two sides of the same coin?

16:40 ¿ 16:50 Discussion

16:50 ¿ 17:20 Herta Flor (ZI Mannheim, Germany)

The contextual modulation of fear: implications for mental disorders

16:40 ¿ 16:50 Discussion

17:30 ¿ 19:00 Poster Session

TUESDAY 26th NOVEMBER 2019

Session 3 Circuits for fear prediction and extinction

Chair: Carmen Sandi

09:00 ¿ 09:30 Andrew Holmes (NIH, Bethesda, USA)

Neural circuits mediating ambiguous threat

09:30 ¿ 09:40 Discussion

09:40 ¿ 10:10 Jelena Radulovic (NW University, Chicago, USA)

Processing valence in episodic memory circuits

10:10 ¿ 10:20 Discussion

10:20 ¿ 10:35 Short Talk 3

10:35 ¿ 10:40 Discussion

10:40 ¿ 11.10 Coffee break

11:10 ¿ 11:40 Valerie Doyère (Paris-Saclay Institute of Neuroscience, France)

The amygdala and the temporal expectation of an aversive stimulus

11:40 ¿ 11:50 Discussion

11:50 ¿ 12:20 Merel Kindt (University of Amsterdam, Netherlands)

Tba

Note

By the end of this short course, students should have improved their understanding of neuronal circuit mechanisms of fear learning

Keywords

Anxiety disorders, Fear, Neuronal circuits

Learning Prerequisites

Recommended courses

Neuroscience 2, 3 (MS-courses)

Assessment methods

The PhD students will actively participate in the Symposium with questions and discussion participation. As a control that the students have reached the learning aims of the course, PhD students will summarize a presentation of their choice during a final 3h block session under the supervision of the course instructors.

Resources

Websites

In the programs

  • Neuroscience (edoc), 2019-2020
    • Semester
    • Exam form
      Oral presentation
    • Credits
      1
    • Subject examined
      State-of-the-Art Topics in Neuroscience Vlll: Fear Learning: from neuronal circuits to translation
    • Lecture
      12 Hour(s)
    • Exercises
      6 Hour(s)

Reference week

Lecture
Exercise, TP
Project, other

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  • Autumn semester
  • Winter sessions
  • Spring semester
  • Summer sessions
  • Lecture in French
  • Lecture in English
  • Lecture in German