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Coursebooks
Scientific project design in translational oncology
BIO-488
Lecturer(s) :
De Palma MicheleHanahan Douglas
Radtke Freddy
Language:
English
Withdrawal
It is not allowed to withdraw from this subject after the registration deadline.Remarque
only one registration per student to a scientific thinking courseSummary
The theme of the course is the role of inflammation in cancer. It focuses on the regulation and multifaceted functions of tumor-associated inflammatory cells, and how they promote or oppose cancer.Content
The theme of this course is the role of inflammation in cancer. It focuses on the regulation and multifaceted functions of tumour-associated inflammatory cells, and how they promote or oppose cancer. The course starts with a short introduction by the teachers, who illustrate the focus of the course and the learning objectives. In the following classes the students analyse, present and discuss research papers that have been agreed with the teachers. The final 3-4 classes are dedicated to the design of a project in translational oncology.
- Part I ¿ Journal clubs. The students develop an encyclopedia of the various inflammatory cell types and subtypes that have hallmark-promoting or antagonizing capabilities. Macrophages, neutrophils, myeloid-derived suppressor cells, natural killer and T cells ¿ or subsets thereof ¿ are defined and discussed. For each cell type/subtype, the students describe and discuss known strategies, genetic or pharmacological, to either impair the cell of interest or reprogram its functions in tumours.
- Part II ¿ Project design. The students design a pre-clinical study that can guide or incentivize clinical trials aimed to ablating or reprogramming a cell of interest in a suitable cancer type.
Keywords
Inflammation; Cancer; Immunity; Macrophage; Myeloid cell; T-cell; Tumor-promoting function; Tumor-antagonizing function; Mouse model of cancer; Cell reprogramming; Pre-clinical trial;
Clinical trial.
Learning Prerequisites
Recommended courses
Cancer biology I and II
Resources
Bibliography
Hanahan and Weinberg, Hallmarks of cancer : The next generation (Cell, 2011)
In the programs
- Life Sciences and Technologies - master program, 2019-2020, Master semester 1
- SemesterFall
- Exam formDuring the semester
- Credits
5 - Subject examined
Scientific project design in translational oncology - Number of places
20 - Lecture
2 Hour(s) per week x 14 weeks - Exercises
3 Hour(s) per week x 14 weeks
- Semester
- Life Sciences and Technologies - master program, 2019-2020, Master semester 3
- SemesterFall
- Exam formDuring the semester
- Credits
5 - Subject examined
Scientific project design in translational oncology - Number of places
20 - Lecture
2 Hour(s) per week x 14 weeks - Exercises
3 Hour(s) per week x 14 weeks
- Semester
- Bioengineering, 2019-2020, Master semester 1
- SemesterFall
- Exam formDuring the semester
- Credits
5 - Subject examined
Scientific project design in translational oncology - Number of places
20 - Lecture
2 Hour(s) per week x 14 weeks - Exercises
3 Hour(s) per week x 14 weeks
- Semester
- Bioengineering, 2019-2020, Master semester 3
- SemesterFall
- Exam formDuring the semester
- Credits
5 - Subject examined
Scientific project design in translational oncology - Number of places
20 - Lecture
2 Hour(s) per week x 14 weeks - Exercises
3 Hour(s) per week x 14 weeks
- Semester
- Life Sciences Engineering, 2019-2020, Master semester 1
- SemesterFall
- Exam formDuring the semester
- Credits
5 - Subject examined
Scientific project design in translational oncology - Number of places
20 - Lecture
2 Hour(s) per week x 14 weeks - Exercises
3 Hour(s) per week x 14 weeks
- Semester
- Life Sciences Engineering, 2019-2020, Master semester 3
- SemesterFall
- Exam formDuring the semester
- Credits
5 - Subject examined
Scientific project design in translational oncology - Number of places
20 - Lecture
2 Hour(s) per week x 14 weeks - Exercises
3 Hour(s) per week x 14 weeks
- Semester
Reference week
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- Autumn semester
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- Lecture in French
- Lecture in English
- Lecture in German