Scientific literature analysis in neuroscience
BIOENG-451 / 4 credits
Teacher: La Manno Gioele
Language: English
Withdrawal: It is not allowed to withdraw from this subject after the registration deadline.
Remark: Only one registration per student to a scientific thinking course
Summary
The goal of this course is to learn to analyze a scientific paper critically, question if the data support the conclusions, and produce constructive referee reports in written or oral form. The papers considered will give an overview of the field of developmental neurobiology.
Content
In this course, you will learn how to read a paper critically and understand its content. We will examine published papers and discuss which conclusions can be justified and which require some wishful thinking. We will dissect papers in the field of 'Developmental Neurobiology', focusing in particular on a molecular and cellular perspective, discussing recent research, as well as classic landmarks. The subareas you will learn about include 'Patterning and Gene Regulation', 'Lineages and Tracing', "Migration and Synaptogenesis", "Single-cell analyses and computation", and "Human development and in vitro models".
Part I (15%) Introductory lectures on Nervous System Development.
Part II (70%) Each week, we will evaluate in class papers: few of the participants will be asked to lead the discussion (in the form of an oral presentation, i.e., a journal club), while the rest of the class will be expected to participate in the discussion, producing a summary of the main findings in the proper context, and an assessment of the strengths and weaknesses of the paper. This will require studying background material so that your presentation places the paper in context.
In part III (15%) students will work in small groups and perform a mini-project where they will reproduce/extend analyses of key papers. The projects will be orally presented by the teams during the last week.
The assessment will be based on your oral presentations, written submissions and participation in the discussions throughout the course during the semester.
Keywords
critical reading, science writing, neurobiology, development, neuroscience
Learning Prerequisites
Required courses
None in particular, but a good knowledge of basic biology, biochemistry, physics, and bioinformatics is desirable.
Important concepts to start the course
MA1-MA3. Extensive background in Biology strongly recommended.
Only one registration per student to a scientific thinking course.
It is not allowed to withdraw from this subject after the registration deadline.
Learning Outcomes
By the end of the course, the student must be able to:
- Demonstrate the ability to place the individual research results within the context of the larger field.
- Critique the content of papers and express this analysis in oral and written form.
- Synthesize a scientific review narrative demonstrating a deep comprehension of the assigned papers
- Assess / Evaluate a related group of research papers.
- Demonstrate the ability to place the individual research results within the context of the larger field.
- Critique the content of papers and express this analysis in oral and written form
- Synthesize a scientific review narrative demonstrating a deep comprehension of the assigned papers
- Assess / Evaluate a related group of research papers
- Analyze data encountered in literature to check for or extend the conclusions of the original paper
Teaching methods
Lectures to give background information required to choose and read the papers.
Group discussion of papers and their contribution to the larger narrative.
Expected student activities
Oral presentation of papers, individually or in group.
Read background literature to present the paper in the appropriate context.
Prepare a written summary and a critical, constructive assessment of the paper.
Final project to test understanding of material and hands-on ability to interact with the specific data.
Assessment methods
Evaluation of the quality of the written summary and assessment reports. In course assessment of the oral presentations, participation in discussions and final project.
Supervision
| Office hours | Yes |
| Assistants | Yes |
| Forum | Yes |
In the programs
- Semester: Fall
- Number of places: 20
- Exam form: During the semester (winter session)
- Subject examined: Scientific literature analysis in neuroscience
- Lecture: 1 Hour(s) per week x 14 weeks
- Exercises: 3 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Number of places: 20
- Exam form: During the semester (winter session)
- Subject examined: Scientific literature analysis in neuroscience
- Lecture: 1 Hour(s) per week x 14 weeks
- Exercises: 3 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Number of places: 20
- Exam form: During the semester (winter session)
- Subject examined: Scientific literature analysis in neuroscience
- Lecture: 1 Hour(s) per week x 14 weeks
- Exercises: 3 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Number of places: 20
- Exam form: During the semester (winter session)
- Subject examined: Scientific literature analysis in neuroscience
- Lecture: 1 Hour(s) per week x 14 weeks
- Exercises: 3 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Number of places: 20
- Exam form: During the semester (winter session)
- Subject examined: Scientific literature analysis in neuroscience
- Lecture: 1 Hour(s) per week x 14 weeks
- Exercises: 3 Hour(s) per week x 14 weeks
- Type: optional