Coursebooks

Neuronal circuits underlying goal-directed behavior

BIO-696

Lecturer(s) :

Crochet Sylvain
Esmaeili Vahid
Petersen Carl
Tamura Keita

Language:

English

Frequency

Every 2 years

Remark

Next time : Winter 2021

Summary

The brain can be viewed as a network of neurons receiving sensory input and carrying out experience- and context-dependent computations through complex synaptic interactions to drive motor output, i.e. behavior. Here, we will study recent advances in knowledge of neural circuits in the mouse brain.

Content

Students will learn state-of-the-art analyses of neuronal circuit function contributing to simple learned goal-directed behaviors in mice. We will critically evaluate current understanding through in depth discussion of various topics, guided by selected papers (Spring semester, Thursdays 9 - 11 am).

 

Week 1 - Thursday 20th February 2020 (Carl Petersen)
Yu J, Hu H, Agmon A, Svoboda K (2019) Recruitment of GABAergic interneurons in the barrel cortex during active tactile behavior. Neuron 104: 412-427. doi: 10.1016/j.neuron.2019.07.027

 

Week 2 - Thursday 27th February 2020 (Keita Tamura)
Takahashi N, Oertner TG, Hegemann P, Larkum ME (2016) Active cortical dendrites modulate perception. Science 354: 1587-1590. doi: 10.1126/science.aah6066

 

Week 3 - Thursday 5th March 2020 (Vahid Esmaeili)
Carrillo-Reid L, Han S, Yang W, Akrouh A, Yuste R (2019) Controlling visually guided behavior by holographic recalling of cortical ensembles. Cell 178: 447-457. doi: 10.1016/j.cell.2019.05.045.

 

Week 4 - Thursday 12th March 2020 (Sylvain Crochet)
Ceballo S, Piwkowska Z, Bourg J, Daret A, Bathellier B (2019) Targeted cortical manipulation of auditory perception. Neuron  doi: 10.1016/j.neuron.2019.09.043.

 

Week 5 - Thursday 19th March 2020 (Keita Tamura)
Wang L, Gillis-Smith S, Peng Y, Zhang J, Chen X, Salzman CD, Ryba NJP, Zuker CS (2018) The coding of valence and identity in the mammalian taste system. Nature 558: 127-131. doi: 10.1038/s41586-018-0165-4

 

Week 6 - Thursday 26th March 2020 (Sylvain Crochet)
Economo MN, Viswanathan S, Tasic B, Bas E, Winnubst J, Menon V, Graybuck LT, Nguyen TN, Smith KA, Yao Z, Wang L, Gerfen CR, Chandrashekar J, Zeng H, Looger LL, Svoboda K (2018) Distinct descending motor cortex pathways and their roles in movement. Nature 563: 79-84. doi: 10.1038/s41586-018-0642-9.

 

Week 7 - Thursday 2nd April 2020 (Carl Petersen)
Gao Z, Davis C, Thomas AM, Economo MN, Abrego AM, Svoboda K, De Zeeuw CI, Li N (2018) A cortico-cerebellar loop for motor planning. Nature 563: 113-116. doi: 10.1038/s41586-018-0633-x.

 

Week 8 - Thursday 9th April 2020 (Vahid Esmaeili)
Inagaki HK, Fontolan L, Romani S, Svoboda K (2019) Discrete attractor dynamics underlies persistent activity in the frontal cortex. Nature 566: 212-217. doi: 10.1038/s41586-019-0919-7.

 

Week 9 - Thursday 23rd April 2020 (Keita Tamura)
Mohebi A, Pettibone JR, Hamid AA, Wong JMT, Vinson LT, Patriarchi T, Tian L, Kennedy RT,  Berke JD (2019) Dissociable dopamine dynamics for learning and motivation. Nature 570: 65-70. doi: 10.1038/s41586-019-1235-y

 

Week 10 - Thursday 30th April 2020 (Carl Petersen)
Allen WE, Chen MZ, Pichamoorthy N, Tien RH, Pachitariu M, Luo L,  Deisseroth K (2019) Thirst regulates motivated behavior through modulation of brainwide neural population dynamics. Science 364: 253-253. doi: 10.1126/science.aav3932

 

Week 11 - Thursday 7th May 2020 (Sylvain Crochet)
Nakajima M, Schmitt LI, Halassa MM (2019) Prefrontal cortex regulates sensory filtering through a basal ganglia-to-thalamus pathway. Neuron 103: 445-458. doi: 10.1016/j.neuron.2019.05.026

 

Week 12 - Thursday 14th May 2020 (Vahid Esmaeili)
Musall S, Kaufman MT, Juavinett AL, Gluf S, Churchland AK (2019) Single-trial neural dynamics are dominated by richly varied movements. Nat Neurosci 22: 1677-1686. doi: 10.1038/s41593-019-0502-4

 

Week 13 - Thursday 21st May 2020 - Ascension holiday - No class

 

Week 14 - Thursday 28th May 2020 (Keita Tamura)
Bari BA, Grossman CD, Lubin EE, Rajagopalan AE, Cressy JI,  Cohen JY (2019) Stable representations of decision variables for flexible behavior. Neuron 103: 922-933. doi: 10.1016/j.neuron.2019.06.001

 

At the end of the course, the students should write a 2-page report on a topic of their choice related to the course content. Submission to Carl Petersen by Friday 12th June 2020. This will be the formal evaluation (pass/fail).

Keywords

Neuronal circuits, Mouse behavior

Learning Prerequisites

Required courses

Strong interest in Neuronal Circuit function

Learning Outcome - to critically evaluate studies of neural circuits and behavior.

In the programs

    • Semester
    • Exam form
       Project report
    • Credits
      2
    • Subject examined
      Neuronal circuits underlying goal-directed behavior
    • Number of places
      8
    • Lecture
      26 Hour(s)

Reference week

 
      Lecture
      Exercise, TP
      Project, other

legend

  • Autumn semester
  • Winter sessions
  • Spring semester
  • Summer sessions
  • Lecture in French
  • Lecture in English
  • Lecture in German