BIOENG-518 / 4 credits

Teacher(s): Turcatti Gerardo, Schneider Bernard, Sordet-Dessimoz Jessica, Knott Graham, Pojer Florence, Warot Xavier, Seitz Arne, Chrast Roman

Language: English

Withdrawal: It is not allowed to withdraw from this subject after the registration deadline.


Summary

This course will describe methods underlying translational approaches from disease modeling and characterization to therapeutic applications. The presented techniques will be complemented by hands-on rotations in the technological platforms of the School of Life Sciences.

Content

Keywords

- Animal models

- Imaging

- Drug discovery

- Gene therapy

 

Learning Outcomes

By the end of the course, the student must be able to:

  • Choose the appropriate model to study a selected biological question
  • Select appropriately histological and imaging technique(s) to design relevant experiments
  • Describe the drug discovery process
  • Illustrate the possibilities and limitations of gene therapy
  • Contextualise theoritical and technical concepts of covered techniques

Transversal skills

  • Use a work methodology appropriate to the task.
  • Collect data.
  • Plan and carry out activities in a way which makes optimal use of available time and other resources.
  • Evaluate one's own performance in the team, receive and respond appropriately to feedback.

Teaching methods

This course will be divided into 7 weeks of theoretical lectures followed by 6 weeks of rotations in participating scientific platforms including Histology Core Facility, Biological Electron Microscopy Facility, Protein Production and Structure Core Facility and Biomolecular Screening Facility. For the platform rotations, students will work in small groups (6-8 students per group) and will perform experimental work in two different platforms (platform 1: weeks 8 to 10 and platform 2: weeks 11 to 13). Regarding the selection of platforms for rotations: we will try to accommodate students' preferences. During the last week (week 14) students will visit the animal facility and the phenotyping unit.

Assessment methods

Written reports covering 2 rotations in platforms and written exam during the last week of the semester.

Supervision

Office hours Yes
Assistants Yes
Forum No

In the programs

  • Semester: Spring
  • Number of places: 24
  • Exam form: During the semester (summer session)
  • Subject examined: Methods: from disease models to therapy
  • Practical work: 4 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Number of places: 24
  • Exam form: During the semester (summer session)
  • Subject examined: Methods: from disease models to therapy
  • Practical work: 4 Hour(s) per week x 14 weeks

Reference week

 MoTuWeThFr
8-9     
9-10     
10-11     
11-12     
12-13     
13-14     
14-15     
15-16     
16-17     
17-18     
18-19     
19-20     
20-21     
21-22