BIO-373 / 4 credits

Teacher(s): Deplancke Bart, Fellay Jacques

Language: English


Summary

The theoretical part of this course covers classical genetics and contemporary genomics. Because the programming language R has become important for genomic research, the course also includes an introduction to R, followed by practical applications to genomic analyses, including a group project.

Content

Learning Outcomes

By the end of the course, the student must be able to:

  • Elaborate on the social and ethical implications of genetics and genomics, including genetic testing and gene therapy
  • Assess / Evaluate the differences between mutations, risk factors and genetic variations
  • Examine the basics of population and quantitative genetics, evolutionary and conservation genetics
  • Describe the architecture of a genome and its function with a specific focus on creating a knowledge base of how the genome interacts with the proteome
  • Analyze the structural and functional properties of gene regulatory networks and how these networks coordinate differential gene expression
  • Explain how solving the human genome sequence is paving the way for personalized medicine
  • Perform basic genomic analyses using R (alignment, differential expression, association study etc.)

Teaching methods

Ex cathedra, exercices and group project

 

Expected student activities

Exercises + group project in "R"

 

Assessment methods

Written exam + report on a project in "R"

 

Supervision

Office hours No
Assistants Yes
Forum Yes

Resources

Virtual desktop infrastructure (VDI)

No

Bibliography

Concepts of Genetics / Klug - 10th edition, ISBN 978-0-321-72412-0
Genomes / Brown - 3rd Edition ISBN 0 8153 4138 5

 

In the programs

  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Genetics and genomics
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Exercises: 1 Hour(s) per week x 14 weeks
  • Project: 1 Hour(s) per week x 14 weeks

Reference week

 MoTuWeThFr
8-9     
9-10     
10-11     
11-12     
12-13     
13-14INM10    
14-15    
15-16INM10    
16-17INM10    
17-18     
18-19     
19-20     
20-21     
21-22     

Monday, 13h - 15h: Lecture INM10

Monday, 15h - 16h: Exercise, TP INM10

Monday, 16h - 17h: Project, other INM10