Coursebooks

Drug discovery and development

CH-317

Lecturer(s) :

Heinis Christian

Language:

English

Summary

This course discusses the molecular basis of diseases and how drugs work. Concepts and processes employed in today's drug discovery and development are covered. The first part of the course focuses on small molecule drugs and the second one on biotherapeutics.

Content

Lectures 1-5: The following five major disease areas as well as small molecule therapeutics applied to treat the diseases are discussed:

·       cancer

·       cadiovascular diseases

·       neurologic disorders

·       infectious diseases

·       inherited diseases

 

Lectures 6-13: The following therapeutic formats being mostly biologics are discussed:

·       blood and blood components

·       enzymes

·       hormones

·       cytokines

·       monoclonal antibodies

·       antibody fragments and mimics

·       macrocycles

·       peptides and peptidomimetics

Keywords

pharmacological chemistry, drug discovery, biotherapeutics, biologics, small molecule drugs

 

Learning Prerequisites

Required courses

Basic knowledge in chemistry and biochemistry

 

Learning Outcomes

By the end of the course, the student must be able to:

Teaching methods

Each week, one of the above described topics is presented in a lecture (45 minutes) and a research paper is discussed (45 minutes).

Expected student activities

The students read each week a research paper and answer questions that are provided (at home). The students participate in the discussion of the paper in the lecture.

 

Assessment methods

Written exam

Resources

Notes/Handbook

The following materials are provided on Moodle:

·       Handout for each lecture

·       PPT presentation of the lectures and the case studies

·       Research papers

·       Questions about research papers

In the programs

Reference week

 MoTuWeThFr
8-9     
9-10     
10-11     
11-12     
12-13     
13-14     
14-15     
15-16     
16-17     
17-18     
18-19     
19-20     
20-21     
21-22     
Under construction
 
      Lecture
      Exercise, TP
      Project, other

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  • Autumn semester
  • Winter sessions
  • Spring semester
  • Summer sessions
  • Lecture in French
  • Lecture in English
  • Lecture in German