Cellular signalling

Summary

Presentation of selected signalling pathways with emphasis on both the mechanism of action of the molecules involved, molecular interactions and the role of their spatio-temporal organization within the cell, considering cellular dimensions and conditions.

Content

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Keywords

Cellular signalling, molecular interactions, space and time, cellular conditions, receptor, ligand, membranes, protein modifications

Learning Prerequisites

Required courses

Biochimie I   (CH-210)

Macromolecular structure and interactions  (CH-311)

Dynamics of biomolecular processes  (CH-312)

Chemical Biology (CH-313)

Recommended courses

Biochemistry II (CH 313)

Reaction kinetics

Important concepts to start the course

Biochemistry, cell and organells, membranes, proteins, biophysical methods. physical chemistry

Learning Outcomes

By the end of the course, the student must be able to:

• Integrate molecular and cellular events
• Discuss cellular signalling pathways
• Analyze scientific literature
• Assess / Evaluate mechanisms of regulation
• Contextualise receptor-ligand interactions
• Elaborate Spatio-temporal organisation and regulation
• Estimate using logical deduction and common senese

Teaching methods

Lectures & discussion

Expected student activities

Active participation to lectures; read and interpret scientific reviews and papers

Assessment methods

Oral exam, without preparation

Supervision

Others

during course or on rendez-vous

Resources

Bibliography

course hand-outs

review and research articles

Notes/Handbook

standard text books

Websites

• http://Moodle

Moodle Link

• https://go.epfl.ch/CH-411