Cellular signalling
Summary
Presentation of selected signalling pathways with emphasis on both the mechanism of action of the molecules involved, molecular interactions and the role of their spatio-temporal organization within the cell, considering cellular dimensions and conditions.
Content
Ligand binding and receptor activation.Receptor systems in plasma membrane, cytosol and nucleus. Lipids, proteins and molecular interactions. Regulation of activity and covalent modification. Spatial and temporal organisation of molecules and signalling efficacy.
Keywords
Cellular signalling, molecular interactions, space and time, cellular conditions, receptor, ligand, membranes, protein modifications
Learning Prerequisites
Required courses
Biochimie I (CH-210)
Macromolecular structure and interactions (CH-311)
Dynamics of biomolecular processes (CH-312)
Chemical Biology (CH-313)
Recommended courses
Biochemistry II (CH 313)
Reaction kinetics
Important concepts to start the course
Biochemistry, cell and organells, membranes, proteins, biophysical methods. physical chemistry
Learning Outcomes
By the end of the course, the student must be able to:
- Integrate molecular and cellular events
- Discuss cellular signalling pathways
- Analyze scientific literature
- Assess / Evaluate mechanisms of regulation
- Contextualise receptor-ligand interactions
- Elaborate Spatio-temporal organisation and regulation
- Estimate using logical deduction and common senese
Teaching methods
Lectures & discussion
Expected student activities
Active participation to lectures; read and interpret scientific reviews and papers
Assessment methods
Oral exam, without preparation
Supervision
| Others | during course or on rendez-vous |
Resources
Bibliography
course hand-outs
review and research articles
Notes/Handbook
standard text books
Websites
Moodle Link
In the programs
- Semester: Fall
- Exam form: Written (winter session)
- Subject examined: Cellular signalling
- Lecture: 2 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Written (winter session)
- Subject examined: Cellular signalling
- Lecture: 2 Hour(s) per week x 14 weeks
- Type: optional