Biomedical optics
Summary
This course addresses the principles governing the interactions between light and biological tissue, their optical properties and basic concepts of radiometry. Illustrative diagnostic and therapeutic applications of light in medicine and photobiology will also be described.
Content
Introduction
Brief history
Introduction to general optics and tissue optics
Radiometry and Photometry
Light dosimetry
Light-tissues interactions
Introduction to molecular spectroscopy
Photosensitizers
Principles and techniques
Absorption, fluorescence and vibrational spectroscopies and imaging.
Time-resolved spectroscopy and imaging.
Light sources, detectors and optical systems.
Applications
Analytical techniques, oxymetry, optical biosensors, Photodetection of early cancers with exogenous and endogenous dyes, Angiography, Phototherapy and Photodynamic therapy, optical coherence tomography.
Keywords
Biomedical photonics, tissue optics, light-tissue interactions, photodiagnosis, phototherapy, light dosimetry, dyes, photosensitizers.
Learning Prerequisites
Important concepts to start the course
Basic background in biology, chemistry and optics.
Learning Outcomes
- Design simple systems used for phototherapy and photodiagnosis.
- Characterize the spectral design of apparatus used in biomedical optics.
- Compute the light dose in biological tissues.
- Identify the optical components to develop an apparatus used in phototherapy.
- Explain the working principles of apparatus used in biomedical optics.
- Model the propagation of light in biological tissues.
- Quantify the light dose in phototherapy.
- Interpret data obtained or published in photomedicine.
- Design simple systems used for phototherapy and photodiagnosis.
- Characterize the spectral design of apparatus used in biomedical optics.
- Compute the light dose in biological tissues.
- Identify the optical components to develop an apparatus used in phototherapy.
- Explain the working principles of apparatus used in biomedical optics.
- Model the propagation of light in biological tissues.
- Quantify the light dose in phototherapy.
- Interpret data obtained or published in photomedicine.
Transversal skills
- Access and evaluate appropriate sources of information.
- Collect data.
- Make an oral presentation.
- Summarize an article or a technical report.
- Communicate effectively with professionals from other disciplines.
Teaching methods
Lectures, Exercises, recent literature review papers, classroom discussion + oral presentation.
Expected student activities
Exercises, lecture of review papers, classroom discussion + oral presentation.
Assessment methods
Oral exam (1/2) + presentation (3/8) + exercices (1/8).
Supervision
| Office hours | Yes |
| Assistants | Yes |
| Forum | No |
Resources
Bibliography
- Optics / Hecht EBOOK
- Optics / Hecht
- Optical-Thermal Response of Laser Irradiated Tissue / Welch
- Photosensitisers in Biomedicine / Wainwright
- Optics / Hecht
- Handbook of Photomedicine / Hamblin
- Quantitative Biomedical Optics / Bigio
- Handbook of Biomedical Fluorescence / Mycek
- Principles of Fluorescence Spectroscopy / Lakowicz
Ressources en bibliothèque
- Optics / Hecht
- Optical-Thermal Response of Laser Irradiated Tissue / Welch
- Handbook of Photomedicine / Hamblin
- Principles of Fluorescence Spectroscopy / Lakowicz
- Photosensitisers in Biomedicine / Wainwright
- Quantitative Biomedical Optics / Bigio
- Handbook of Biomedical Fluorescence / Mycek
Notes/Handbook
Slides available on Moodle.
Moodle Link
Prerequisite for
Master. Academic research and R/D activities in the industry of this field
In the programs
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Biomedical optics
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 1 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Biomedical optics
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 1 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Biomedical optics
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 1 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Biomedical optics
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 1 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Biomedical optics
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 1 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Biomedical optics
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 1 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Biomedical optics
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 1 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Biomedical optics
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 1 Hour(s) per week x 14 weeks
- Type: optional
- Exam form: Oral (winter session)
- Subject examined: Biomedical optics
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 1 Hour(s) per week x 14 weeks
- Type: optional
- Semester: Fall
- Exam form: Oral (winter session)
- Subject examined: Biomedical optics
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 1 Hour(s) per week x 14 weeks
- Type: optional