BIOENG-442 / 4 credits

Teacher(s): Lütolf Matthias, Ghezzi Diego

Language: English


Summary

This course covers the fundamental concepts behind the design, function and application of state-of-the-art biomaterials, that is, materials that are designed based on a molecular understanding of their interactions with biological systems.

Content

Keywords

Cells, extracellular matrix, tissue, regeneration, angiogenesis, biodegradable materials, hydrogels, drug delivery, micro- and nano-particles, self-assembly, high-throughput screening, stem cell engineering, materials for immunemodulation

Learning Prerequisites

Recommended courses

Materials science for bioengineers (BIOENG-315)

Biology I (BIO-103)

Stem cell biology and technology (BIO-447)

Learning Outcomes

By the end of the course, the student must be able to:

  • Elaborate key effectors and their functions driving protein- and cell-materials interactions
  • Formulate the basics of inflammation induced by materials in the body
  • Elaborate the basics of stem cell function and tissue regeneration, and how materials can influence regeneration
  • Systematize the different general applications of biomaterials
  • Contextualise specific examples of biomaterials on the basis of application and understands their selection criteria
  • Judge the suitability of a material for a certain application based on structure-property relationships
  • Formalize the key concepts in the molecular engineering of bioactivity and bioresponsiveness

Transversal skills

  • Assess one's own level of skill acquisition, and plan their on-going learning goals.
  • Make an oral presentation.
  • Demonstrate a capacity for creativity.
  • Continue to work through difficulties or initial failure to find optimal solutions.
  • Evaluate one's own performance in the team, receive and respond appropriately to feedback.
  • Communicate effectively, being understood, including across different languages and cultures.
  • Use a work methodology appropriate to the task.
  • Set objectives and design an action plan to reach those objectives.
  • Plan and carry out activities in a way which makes optimal use of available time and other resources.

Teaching methods

  • Ex cathedra
  • Group case study

Expected student activities

  • Reading key literature before each course as preparation
  • Group case study

Assessment methods

  • Group project: 40%
  • Written exam: 60%

Resources

Bibliography

Comprehensive Biomaterials, 1st edition, Paul Ducheyene et al., Elsevier (2011)

Principles of Tissue Engineering, Editors Lanza, Langer &Vacanti, Elsevier (2007)

Ressources en bibliothèque

Notes/Handbook

Will be provided on moodle webpage before each lecture

In the programs

  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Biomaterials
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Biomaterials
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Biomaterials
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Biomaterials
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Biomaterials
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Biomaterials
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Biomaterials
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Biomaterials
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks
  • Semester: Spring
  • Exam form: Written (summer session)
  • Subject examined: Biomaterials
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Exercises: 2 Hour(s) per week x 14 weeks

Reference week

 MoTuWeThFr
8-9     
9-10     
10-11     
11-12     
12-13     
13-14     
14-15     
15-16     
16-17     
17-18     
18-19     
19-20     
20-21     
21-22