Biological chemistry II
Summary
Biochemistry is a key discipline in the Life Sciences. Biological Chemistry I and II are two tightly interconnected courses that aims to understand in molecular terms the processes that make life possible.
Content
In Biological Chemistry II we will focus on cell metabolism to understand how the molecules that constitute living beings are produced, modified and used for energetic purposes. A specific emphasis will be put on the understanding of organizing principles in metabolism and on the regulatory circuits living beings have evolved to control their metabolic outputs.
- Bioenergetics and cell metabolism (I)
[Glycolysis-TCA cycle-PPP-oxidative phosphorylation-B oxidation-AA oxydation]
- Bioenergetics and cell metabolism (II)
[Energy storage TAG synthesis and gluconeogenesis]
- Bioenergetics and cell metabolism (III)
[Energy and nutrient sensing cell growth/ autophagy]
- Bioenergetics and cell metabolism (IV)
[Cellular metabolic specialization, liver muscle and adipose tissue metabolism]
- Enzymology (I)
[Enzymes regulation by PTMs]
- Enzymology (II)
[Methods to study enzymatic regulation/ proteomics]
- Enzymology (III)
[Engineering enzymes]
- Building a Cell (I)
[Carbohydrate biosynthesis, AA, and NA biosynthesis]
- Building a Cell (II)
[Lipid biosynthesis]
- Building a Cell (III)
[Compartmentalization]
- Metabolic circuits (I)
[Feedback mechanisms and metabolic network motifs]
- Metabolic circuits (II)
[Metabolic Teleonomy and Metabolic Biases]
Keywords
Energy Metabolism, Enzymology, Biosynthetic Pathways, Metabolic Circuits
Learning Prerequisites
Required courses
Biological Chemistry I
Recommended courses
General Biology, Organic chemistry
Important concepts to start the course
- Basic understanding of chemical composition of biological matter
- Basic understanding of cell organization
- Basic understanding of protein structure and function
- Basic reaction mechanisms in organic chemistry
Learning Outcomes
By the end of the course, the student must be able to:
- Recognize biochemical pathways
- Integrate cell compartmentalisation and metabolism
- Interpret the topology of metabolic circuits
Transversal skills
- Assess one's own level of skill acquisition, and plan their on-going learning goals.
- Continue to work through difficulties or initial failure to find optimal solutions.
- Demonstrate the capacity for critical thinking
- Access and evaluate appropriate sources of information.
Teaching methods
- Lectures
- Exercise session accompanying each lecture
- Exercise session on bioinformatics and protein structure visualization tools
Expected student activities
- Attendance to classes
- Attendance to exercises
- Class participation
Assessment methods
- Written exam
Supervision
| Office hours | Yes |
| Assistants | Yes |
| Forum | Yes |
Resources
Virtual desktop infrastructure (VDI)
No
Bibliography
Ressources en bibliothèque
Moodle Link
In the programs
- Semester: Spring
- Exam form: Written (summer session)
- Subject examined: Biological chemistry II
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 2 Hour(s) per week x 14 weeks