Fiches de cours

The making of an innovative medicine


Lecturer(s) :

Clerc Roger G.




Every year


To expose participants to translational research (from bench to bedside and back) and drug discovery


Through a logical series of presentations both from the participants and the lecturer (flipped classroom format, oral presentations, workshops) on the making of an innovative medicine, the entire and complex process starting from the therapeutic target identification up until the clinical development and use in clinical practice of a new molecular entity (NME) will be addressed and discussed.

The course is divided in twelve sections of each 2 periods of 45 minutes :


Section 1          Scope of the course,  general organization, case study

Section 2          Historical perspective, the modern pharmacy

Section 3          Translational research: crossing the bridge: from bench to bedside and back

Section 4          Therapeutic target identification, several case studies

Section 5          Structure based drug design: the impact of medicinal chemistry, MDO, HTS

Section 6          Therapeutic modalities, peptides, DNA, RNA therapeutics, biologicals

Section 7          Personalized healthcare (PHC)  and precision medicine, biomarkers

Section 8          Pharmacogenomics, pharmacogenetical polymorphisms

Section 9          In vivo pharmacology, investigative toxicology, drug safety

Section 10         Clinical research, phase 0, phase I, ii, iii, iv, do what patients need next

Section 11         Intellectual property, patents, scientific and clinical integrity

Section 12         Future medical breakthrough, somatic diseased gene editing


Minimum 4 participants

Maximum 25 participants


This interactive introductory course to drug discovery and translational biomedical research (from the bench to bedside and back) involves an active participation of the attendants in form of in classroom presentations. A detailed instruction for authors is made available at the beginning of the course. The presentations serve as course evaluation.

Learning Outcomes


Translational biomedical research/Drug discovery

Learning Prerequisites

Required courses

Basic Molecular Biology, Cellular Signaling, Pharmacology



'A prescription for change : the looming crisis in drug development' Pr M. Kinch UNC  Press(2017) ISBN 978-1-4696-3062-5

In the programs

Reference week

      Exercise, TP
      Project, other


  • Autumn semester
  • Winter sessions
  • Spring semester
  • Summer sessions
  • Lecture in French
  • Lecture in English
  • Lecture in German