Fiches de cours 2017-2018

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Scientific project design in drug discovery

BIO-494

Enseignant(s) :

Auwerx Johan
Cole Stewart

Langue:

English

Withdrawal

It is not allowed to withdraw from this subject after the registration deadline.

Remarque

only one registration per student to a scientific thinking course

Summary

The goal of this course is to instruct the student how fundamental scientific knowledge can be applied for drug discovery and development. We will demonstrate these principles with examples, including obesity, diabetes, atherosclerosis and infectious diseases such as HIV/AIDS and tuberculosis.

Content

General principles of drug development [target-based versus whole cell-based screens, target identification, target validation, screening, hit to lead optimization, rational drug design, process research (optimization of the chemical synthesis for the pilot plant and factory), efficacy, toxicity / safety, preclinical & clinical development, ,..]

Keywords

Drug discovery

Drug development

Drug targets

Screening

ADME/T

Drug-drug interactions

Pharmacology

Learning Prerequisites

Required courses

Bachelor in Life Sciences, Physical Sciences, Pharmacology or equivalent

Recommended courses

Infection biology

Physiology

Chemistry

Biochemistry

Pharmacology

Important concepts to start the course

History of chemotherapy and the design of randomised clinical trials. Nature of drug targets and the mechanisms of action of some commonly used drugs and antibiotics.  Hit-finding, hit-to-lead and lead optimisation towards a candidate drug.

Learning Outcomes

By the end of the course, the student must be able to:

Transversal skills

Teaching methods

After ex-cathedra introduction sessions, detailing the pathophysiology of some common metabolic diseases and selected infectious diseases, the teaching proceeds with weekly sessions of office hours and group work in close collaboration with the teachers. Scientific publications will be analyzed by individual students and presented to the group.

Expected student activities

Database searches

Literature reviews

Analysis of scientific articles

Presentation of salient points

Discussion of findings in a more general context

Assessment methods

 

Resources

Bibliography

Ressources en bibliothèque

Prerequisite for

Masters

Dans les plans d'études

Semaine de référence

 LuMaMeJeVe
8-9    
9-10    
10-11     
11-12     
12-13     
13-14     
14-15     
15-16     
16-17     
17-18     
18-19     
19-20     
20-21     
21-22     
 
      Cours
      Exercice, TP
      Projet, autre

légende

  • Semestre d'automne
  • Session d'hiver
  • Semestre de printemps
  • Session d'été
  • Cours en français
  • Cours en anglais
  • Cours en allemand