Fiches de cours 2017-2018

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Molecular and cellular biophysic II

CH-312

Enseignant(s) :

Fierz Beat
Hovius Rudolf

Langue:

English

Summary

In this course we will discuss advanced biophysical topics using classical and current literature, building on the framework established in the course Molecular and Cellular Biophysics I. The course is held in English.

Content

1 Protein folding / substates / dynamics

' molecular chaperones and protein folding in the cell

' conformational fluctuations in protein function and regulation

' natively disordered proteins

2 Protein machines

' motor proteins in trafficking

' motor proteins in DNA and chromatin transactions

3 DNA binding proteins / transcription

' protein DNA interactions

' search processes in the nucleus

' dynamics and function of the transcription machinery

4 Channels and receptors

' ion channels, receptors

' detection of physical and chemical stimuli

5 Membranes

' fusion, fission, membrane deformation

' diffusion

 

Keywords

protein folding, dynamics, molecular machines, DNA, transcription, receptors, membrane, diffusion,  trafficking

 

 

Learning Prerequisites

Required courses

Molecular and Cellular Biophysics I

Biochemistry I

Chemical thermodynamics

 

 

Recommended courses

Biochemistry II

 

 

Important concepts to start the course

Protein structure, folding, function and dynamics

Theoretical biophysics, thermodynamics, chemical kinetics

Membranes and lipids

 

 

Learning Outcomes

By the end of the course, the student must be able to:

Transversal skills

Teaching methods

Ex cathedra and student presentations / discussions.

 

 

Expected student activities

Preparation of articles

Presentations of articles from the classical and current literature

Active participation to discussions

 

Assessment methods

Written exam

 

 

Supervision

Office hours No
Assistants No
Forum No
Others

Moodle

 

Resources

Bibliography

Literature articles / reviews

"Biophysical Chemistry", Cantor and Schimmel, Vols 1-3 (Freeman, New York 1980)

"Molecular and Cellular Biophysics", Meyer B. Jackson (Cambridge University Press, 2006)

Ressources en bibliothèque

Prerequisite for

CH-413 Nanobiotechnology and Biophysics

CH-419 Cellular Signalling

 

Dans les plans d'études

    • Semestre
       Printemps
    • Forme de l'examen
       Ecrit
    • Crédits
      2
    • Matière examinée
      Molecular and cellular biophysic II
    • Cours
      2 Heure(s) hebdo x 14 semaines
  • Passerelle HES - CGC, 2017-2018, Semestre printemps
    • Semestre
       Printemps
    • Forme de l'examen
       Ecrit
    • Crédits
      2
    • Matière examinée
      Molecular and cellular biophysic II
    • Cours
      2 Heure(s) hebdo x 14 semaines

Semaine de référence

 LuMaMeJeVe
8-9     
9-10     
10-11     
11-12     
12-13     
13-14     
14-15     
15-16     
16-17     
17-18     
18-19     
19-20     
20-21     
21-22     
En construction
 
      Cours
      Exercice, TP
      Projet, autre

légende

  • Semestre d'automne
  • Session d'hiver
  • Semestre de printemps
  • Session d'été
  • Cours en français
  • Cours en anglais
  • Cours en allemand