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Fundamentals of biosensors and electronic biochips

EE-515

Enseignant(s) :

Guiducci Carlotta

Langue:

English

Withdrawal

It is not allowed to withdraw from this subject after the registration deadline.

Summary

The labels "biosensor"€ and "eBiochip" have been employed to refer to the most diverse systems and in several fields of application. The course is meant not only to provide means to dig into this sea but also a thoughtful understanding of the detection principles and a design perspective.

Content

PART I Fundamentals

§Ch 0 Laying the foundations.

§More definitions (assay, diagnostics, ¿); §Parameters qualifying a sensor.

§Ch 1 Possible configurations of a biosensing system.

§Area confined and surface confined. §Miniaturization consequences

§Ch 2 The solid/liquid interface

§Electrical properties §Optical properties §Surface chemistry to make a surface sense. Specificity

§Ch 3 Systems working in dynamic regime

§Sensors in flow chambers or in channels §Large consequences of going Nano

PART 2 Detection principles and analysis

§ Detection principles

§Charge transfer § Probing interface electrical parameters § Probing interface optical parameters § Characterizing mass change on a surface § Perturbation of electrical field in hybrid electron devices (transistor)

§Case studies of micro/nanosensors and high throughput systems

Learning Prerequisites

Recommended courses

Understanding Statistics and Experimental Design

Related courses:

BioMEMS

Bioanalytics and analytical sensors

Important concepts to start the course

The course is hystorically addressed to students with many sorts of background.

When needed, the premises for the understanding of certain topics are outlined and discussed during the course.

In particular, the course would require some familiarity with the fundamentals of molecular biology and a solid physics background.

Instrumental prerequisites that span from electrode/solution interfaces, to binding kinetics, to electrical characterization of biological elements, to microelectronic proccesses are recalled and integrated in the course material.

Learning Outcomes

By the end of the course, the student must be able to:

Transversal skills

Teaching methods

§3 credits

§2/3 Frontal lecture.

1/3 exercises

Expected student activities

§Come to classes

§Study assigned material

§Prepare exercise before the session

Assessment methods

§Written exam (end of the semester)

Supervision

Office hours Yes
Assistants Yes
Others office hours on appointment

Resources

Bibliography

A selection of chapters from the books listed below is proposed to explore some topics and deepen understanding. The list is non exhaustive of the concerned literature and does not cover the entire content of the course that is supported by the slides and by selected scientific journal papers.

Bioelectronics handbook, M. Grattarola, G. Massobrio, Ms Graw Hill - (Part 2, Ch 8, Ch 9 Ch 10)

Intermolecular and Surface Forces, J. Israelachvili, Academic press, (in particular Ch 12)

Surface Design: Applications in Bioscience and Nanotechnology, R. Forch, H. Schonherr, A.T. Jenkins, Wiley, (Ch 1, Ch 3.3, App F)

Bioelectronics, I. WIllner, E. Katz, Wiley-VCH, (Ch 5, Ch 8)

Handbook fo Surface Plasmon Resonance, RBM Scasfoort, A. Tudos, RSC, (Ch 1, Ch 4, Ch 5)

Ressources en bibliothèque
Notes/Handbook

The course material is made available on the moodle.

Moodle Link

Dans les plans d'études

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    • Semestre
      Automne
    • Forme de l'examen
      Ecrit
    • Crédits
      3
    • Matière examinée
      Fundamentals of biosensors and electronic biochips
    • Nombre de places
      70
    • Cours
      2 Heure(s) hebdo x 14 semaines
    • Exercices
      1 Heure(s) hebdo x 14 semaines
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    • Semestre
      Automne
    • Forme de l'examen
      Ecrit
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      3
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      Fundamentals of biosensors and electronic biochips
    • Nombre de places
      70
    • Cours
      2 Heure(s) hebdo x 14 semaines
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Semaine de référence

LuMaMeJeVe
8-9
9-10
10-11
11-12
12-13
13-14 MXF1
14-15
15-16 MXF1
16-17
17-18
18-19
19-20
20-21
21-22
Cours
Exercice, TP
Projet, autre

légende

  • Semestre d'automne
  • Session d'hiver
  • Semestre de printemps
  • Session d'été
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