Coursebooks 2017-2018

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Caution, these contents corresponds to the coursebooks of last year


Scientific project design in translational oncology

BIO-488

Lecturer(s) :

De Palma Michele
Hanahan Douglas
Radtke Freddy

Language:

English

Withdrawal

It is not allowed to withdraw from this subject after the registration deadline.

Summary

The theme of the course is the role of inflammation in cancer. It focuses on the regulation and multifaceted functions of tumor-associated inflammatory cells, and how they promote or oppose cancer.

Content

The course will start with a short introduction by the teachers, who illustrate the focus of the course and the learning objectives. In the remaining classes the students will analyze, present and discuss research papers that have been agreed with the teachers.

Part I ' Develop an encyclopedia

The students develop an encyclopedia of the various inflammatory cell types and subtypes that have hallmark-promoting or antagonizing capabilities. Macrophages (i), neutrophils (ii), myeloid-derived suppressor cells (MDSCs), T cells (iv) ' or subsets thereof ' will be defined
and discussed with respect to their tumor-promoting or antagonizing functions.

Part II ' To kill or reprogram?

For each cell type/subtype, the students describe and discuss known strategies ' genetic or pharmacological ' to either kill the cell of interest or reprogram its functions in tumors.

Part III ' Translation to cancer therapy

For each cell type/subtype, the students design pre-clinical studies that can guide or incentivize clinical studies aimed at ablating or reprogramming the cell of interest in a suitable cancer type.

Keywords

Inflammation; Cancer; Immunity; Macrophage; Myeloid cell; T-cell; Tumor-promoting function; Tumor-antagonizing function; Mouse model of cancer; Cell reprogramming; Pre-clinical trial;
Clinical trial.

Learning Prerequisites

Recommended courses

Cancer biology I and II

Learning Outcomes

Resources

Bibliography

Hanahan and Weinberg, Hallmarks of cancer : The next generation (Cell, 2011)

Ressources en bibliothèque

In the programs

Reference week

 MoTuWeThFr
8-9  CM1104  
9-10    
10-11     
11-12     
12-13     
13-14     
14-15     
15-16     
16-17     
17-18     
18-19     
19-20     
20-21     
21-22     
 
      Lecture
      Exercise, TP
      Project, other

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  • Autumn semester
  • Winter sessions
  • Spring semester
  • Summer sessions
  • Lecture in French
  • Lecture in English
  • Lecture in German