Coursebooks 2017-2018

PDF
 

Physical biology I

BIO-243

Lecturer(s) :

De Los Rios Paolo

Language:

English

Summary

This course aims at introducing the basic notions of equilibrium and non-equilibrium statistical mechanics that are necessary to formulate quantitative, rigorous and predictive models of biological systems. Formal lectures will alternate with applications to biological systems and with exercises.

Content

  1. Introduction: the need for a probabilistic description of biological systems
  2. The formalism of statistical mechanics: free energy, Boltzmann distribution, partition function
  3. Diffusion and transport
  4. Rate equations: connection between equilibrium and kinetics; what is the rate?
  5. Electrostatics in physiological solutions
  6. Macromolecular crowding: the complex cytoplasm
  7. Non-equilibrium processes in the cell: using energy to beat the second principle of thermodynamics

Learning Prerequisites

Required courses

All the general physics and analysis courses; probability and statistics.

Learning Outcomes

By the end of the course, the student must be able to:

Assessment methods

Written exam

Resources

Notes/Handbook

Notes will be distributed by the instructor.

In the programs

Reference week

 MoTuWeThFr
8-9     
9-10     
10-11CE1106  CE1105 
11-12   
12-13     
13-14     
14-15     
15-16     
16-17     
17-18     
18-19     
19-20     
20-21     
21-22     
 
      Lecture
      Exercise, TP
      Project, other

legend

  • Autumn semester
  • Winter sessions
  • Spring semester
  • Summer sessions
  • Lecture in French
  • Lecture in English
  • Lecture in German