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Chemical biology

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Chemical biology

CH-412

Lecturer(s) :

Aye Yimon
Ferreira De Sousa Correia Bruno Emanuel
Heinis Christian
Hovius Rudolf

Language:

English

Summary

The class will discuss how the tools of chemistry can be utilized to address important problems in biology. Through the discussion of landmark papers in chemical biology the students will be introduced into research at the interface of chemistry and biology.

Content

Keywords

chemical biology, protein chemistry, chemical probes, protein engineering, chemical genetics

Learning Outcomes

By the end of the course, the student must be able to:

Characterize the main concepts in chemical biology
Design an experiment to engineer an autofluorescent protein
Describe how proteins can be chemically modified in live cells
Develop an experiment to exploit unnatural amino acids
Describe a strategy to generate allele-specific kinase inhibitors
Categorize different strategies to derivatize proteins for mechanistic studies
Contrast forward and reverse chemical genetics
Develop a strategy for determining the protein target of a bioactive molecule

Transversal skills

Access and evaluate appropriate sources of information.

Teaching methods

Ex cathedera and discussions

Expected student activities

Read papers to be discussed before the class

Assessment methods

100% Oral exam

Supervision

Office hours	No
Assistants	No
Forum	No
Others	Students are welcomed to contact Kai Johnsson via email or after the class to schedule appointments

Resources

Ressources en bibliothèque

Notes/Handbook

Papers and slides will be distributed via the the website of the teaching section or by email before the class.

Websites

http://scgc.epfl.ch/telechargement_cours_chimie

In the programs

Bioengineering, 2018-2019, Master semester 2
- Semester
  Spring
- Exam form
  Written
- Credits
  3
- Subject examined
  Chemical biology
- Lecture
  2 Hour(s) per week x 14 weeks
Bioengineering, 2018-2019, Master semester 4
- Semester
  Spring
- Exam form
  Written
- Credits
  3
- Subject examined
  Chemical biology
- Lecture
  2 Hour(s) per week x 14 weeks
Molecular & Biological Chemistry, 2018-2019, Master semester 2
- Semester
  Spring
- Exam form
  Written
- Credits
  3
- Subject examined
  Chemical biology
- Lecture
  2 Hour(s) per week x 14 weeks
Molecular & Biological Chemistry, 2018-2019, Master semester 4
- Semester
  Spring
- Exam form
  Written
- Credits
  3
- Subject examined
  Chemical biology
- Lecture
  2 Hour(s) per week x 14 weeks
Life Sciences Engineering, 2018-2019, Master semester 2
- Semester
  Spring
- Exam form
  Written
- Credits
  3
- Subject examined
  Chemical biology
- Lecture
  2 Hour(s) per week x 14 weeks
Life Sciences and Technologies - master program, 2018-2019, Master semester 2
- Semester
  Spring
- Exam form
  Written
- Credits
  3
- Subject examined
  Chemical biology
- Lecture
  2 Hour(s) per week x 14 weeks
Life Sciences and Technologies - master program, 2018-2019, Master semester 4
- Semester
  Spring
- Exam form
  Written
- Credits
  3
- Subject examined
  Chemical biology
- Lecture
  2 Hour(s) per week x 14 weeks
Neuroscience (edoc), 2018-2019
- Semester
  Spring
- Exam form
  Written
- Credits
  3
- Subject examined
  Chemical biology
- Lecture
  2 Hour(s) per week x 14 weeks

Reference week

	Mo	Tu	We	Th	Fr
8-9
9-10
10-11
11-12
12-13
13-14	CE1105
14-15	CE1105
15-16
16-17
17-18
18-19
19-20
20-21
21-22

Lecture

Exercise, TP

Project, other

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Autumn semester
Winter sessions
Spring semester
Summer sessions

Lecture in French
Lecture in English
Lecture in German