Cellular and molecular biology I
Summary
The course covers the regulation of gene expression, which translates the information contained in the genome into function, by adjusting the levels and activities of mRNAs and proteins to the needs of specific cells, tissues and environments. A particular emphasis is given on experimental methods.
Content
The course contents include notably the structure of genomes, methods to analyze and manipulate DNA, genetics and functional genomics, as well as the regulation of gene expression from DNA all the way to the post-translational level. An emphasis is placed on discussing experimental approaches that allow the analysis of these processes. The weekly lectures (2 hours) are followed by theoretical exercises (1 hour). The acquisition of knowledge is assessed in a written exam.
Keywords
DNA, genome, genetics, functional genomics, gene expression, transcription, splicing, translation, mechanistic approaches, research strategies
Learning Prerequisites
Required courses
Biologie I
Recommended courses
None
Important concepts to start the course
Those covered in Biologie I
Learning Outcomes
By the end of the course, the student must be able to:
- Describe the basic organization of the genome
- Explain the fundamentals of gene expression
- Deduce conclusions from experimental data
- Realize which research methods are appropriate for solving given questions
- Propose experimental designs to investigate biological questions
- Interpret an experimental result.
Teaching methods
The course is organized in two-hours of lectures plus one-hour of exercises each week. Teaching assistants are present during the exercise sessions.
Expected student activities
In addition to attending the lectures and participating actively to the exercises, students are expected to read the chapters of Alberts indicated by the teachers and that are relevant for the course. Two hours of personal study per week are expected.
Assessment methods
Written exam
Supervision
| Others |
Resources
Bibliography
Molecular Biology of the Cell, 5th edition
Alberts et al., 2007
Garland
Ressources en bibliothèque
Notes/Handbook
The lecture slides will be made available through Moodle.
Moodle Link
Prerequisite for
Integrated laboratory in Life Sciences
In the programs
- Semester: Fall
- Exam form: Written (winter session)
- Subject examined: Cellular and molecular biology I
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 2 Hour(s) per week x 14 weeks
- Semester: Fall
- Exam form: Written (winter session)
- Subject examined: Cellular and molecular biology I
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 2 Hour(s) per week x 14 weeks
- Semester: Fall
- Exam form: Written (winter session)
- Subject examined: Cellular and molecular biology I
- Lecture: 2 Hour(s) per week x 14 weeks
- Exercises: 2 Hour(s) per week x 14 weeks
Reference week
| Mo | Tu | We | Th | Fr | |
| 8-9 | |||||
| 9-10 | |||||
| 10-11 | |||||
| 11-12 | |||||
| 12-13 | |||||
| 13-14 | |||||
| 14-15 | |||||
| 15-16 | |||||
| 16-17 | |||||
| 17-18 | |||||
| 18-19 | |||||
| 19-20 | |||||
| 20-21 | |||||
| 21-22 |
Légendes:
Lecture
Exercise, TP
Project, other