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Coursebooks
Biomaterials
BIOENG-442
Lecturer(s) :
Ghezzi DiegoLütolf Matthias
Language:
English
Summary
This course covers the fundamental concepts behind the design, function and application of state-of-the-art biomaterials, that is, materials that are designed based on a molecular understanding of their interactions with biological systems.Content
Part I: Biological fundamentals
- Cells, extracellular matrices and tissues
- Proteins and protein adsorption, immunological aspects of biomaterials
- Stem cells and tissue regeneration
- Angiogenesis
Part II: Biomaterials classes
- Biomaterials for devices, structural and chemically degradable biomaterials
- Micro- and nanoparticles
- Extracellular matrix-mimicking biomaterials
- Hydrogels as biomaterials
- Self-assembly and supramolecular biomaterials
- Biomaterials for gene delivery and vaccination
Part III: Emerging design and applications of biomaterials
- Tailoring materials for stem cell biology
- Biomaterials for tissue engineering
- Biomaterials for modulation of the immune system
- Biomaterials for neuroengineering
- Biomaterials in medical devices
Keywords
Cells, extracellular matrix, tissue, regeneration, angiogenesis, biodegradable materials, hydrogels, drug delivery, micro- and nano-particles, self-assembly, high-throughput screening, stem cell engineering, materials for immunemodulation
Learning Prerequisites
Recommended courses
Materials science for bioengineers (BIOENG-315)
Biology I (BIO-103)
Stem cell biology and technology (BIO-447)
Learning Outcomes
By the end of the course, the student must be able to:- Elaborate key effectors and their functions driving protein- and cell-materials interactions
- Formulate the basics of inflammation induced by materials in the body
- Elaborate the basics of stem cell function and tissue regeneration, and how materials can influence regeneration
- Systematize the different general applications of biomaterials
- Contextualise specific examples of biomaterials on the basis of application and understands their selection criteria
- Judge the suitability of a material for a certain application based on structure-property relationships
- Formalize the key concepts in the molecular engineering of bioactivity and bioresponsiveness
Transversal skills
- Assess one's own level of skill acquisition, and plan their on-going learning goals.
- Make an oral presentation.
- Demonstrate a capacity for creativity.
- Continue to work through difficulties or initial failure to find optimal solutions.
- Evaluate one's own performance in the team, receive and respond appropriately to feedback.
- Communicate effectively, being understood, including across different languages and cultures.
- Use a work methodology appropriate to the task.
- Set objectives and design an action plan to reach those objectives.
- Plan and carry out activities in a way which makes optimal use of available time and other resources.
Teaching methods
- Ex cathedra
- Group case study
Expected student activities
- Reading key literature before each course as preparation
- Group case study
Assessment methods
- Group project: 30%
- Written exam: 70%
Supervision
Office hours | Yes |
Assistants | Yes |
Forum | Yes |
Resources
Bibliography
Comprehensive Biomaterials, 1st edition, Paul Ducheyene et al., Elsevier (2011)
Principles of Tissue Engineering, Editors Lanza, Langer &Vacanti, Elsevier (2007)
Ressources en bibliothèque
Notes/Handbook
Will be provided on moodle webpage before each lecture
Moodle Link
In the programs
- SemesterSpring
- Exam formWritten
- Credits
4 - Subject examined
Biomaterials - Lecture
2 Hour(s) per week x 14 weeks - Exercises
2 Hour(s) per week x 14 weeks
- Semester
- SemesterSpring
- Exam formWritten
- Credits
4 - Subject examined
Biomaterials - Lecture
2 Hour(s) per week x 14 weeks - Exercises
2 Hour(s) per week x 14 weeks
- Semester
- SemesterSpring
- Exam formWritten
- Credits
4 - Subject examined
Biomaterials - Lecture
2 Hour(s) per week x 14 weeks - Exercises
2 Hour(s) per week x 14 weeks
- Semester
- SemesterSpring
- Exam formWritten
- Credits
4 - Subject examined
Biomaterials - Lecture
2 Hour(s) per week x 14 weeks - Exercises
2 Hour(s) per week x 14 weeks
- Semester
- SemesterSpring
- Exam formWritten
- Credits
4 - Subject examined
Biomaterials - Lecture
2 Hour(s) per week x 14 weeks - Exercises
2 Hour(s) per week x 14 weeks
- Semester
- SemesterSpring
- Exam formWritten
- Credits
4 - Subject examined
Biomaterials - Lecture
2 Hour(s) per week x 14 weeks - Exercises
2 Hour(s) per week x 14 weeks
- Semester
- SemesterSpring
- Exam formWritten
- Credits
4 - Subject examined
Biomaterials - Lecture
2 Hour(s) per week x 14 weeks - Exercises
2 Hour(s) per week x 14 weeks
- Semester
- SemesterSpring
- Exam formWritten
- Credits
4 - Subject examined
Biomaterials - Lecture
2 Hour(s) per week x 14 weeks - Exercises
2 Hour(s) per week x 14 weeks
- Semester
Reference week
Mo | Tu | We | Th | Fr | |
---|---|---|---|---|---|
8-9 | CM1105 | ||||
9-10 | |||||
10-11 | CM1105 | ||||
11-12 | |||||
12-13 | |||||
13-14 | |||||
14-15 | |||||
15-16 | |||||
16-17 | |||||
17-18 | |||||
18-19 | |||||
19-20 | |||||
20-21 | |||||
21-22 |
Lecture
Exercise, TP
Project, other
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- Autumn semester
- Winter sessions
- Spring semester
- Summer sessions
- Lecture in French
- Lecture in English
- Lecture in German